New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs

Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and progn...

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Autores principales: Mahjoubin-Tehran, Maryam, Rezaei, Samaneh, Jesmani, Amin, Birang, Nafise, Morshedi, Korosh, Khanbabaei, Hashem, Khan, Haroon, Piranviseh, Ashkan, Nejati, Majid, Aschner, Michael, Mirzaei, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222190/
https://www.ncbi.nlm.nih.gov/pubmed/34044272
http://dx.doi.org/10.1016/j.biopha.2021.111753
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author Mahjoubin-Tehran, Maryam
Rezaei, Samaneh
Jesmani, Amin
Birang, Nafise
Morshedi, Korosh
Khanbabaei, Hashem
Khan, Haroon
Piranviseh, Ashkan
Nejati, Majid
Aschner, Michael
Mirzaei, Hamed
author_facet Mahjoubin-Tehran, Maryam
Rezaei, Samaneh
Jesmani, Amin
Birang, Nafise
Morshedi, Korosh
Khanbabaei, Hashem
Khan, Haroon
Piranviseh, Ashkan
Nejati, Majid
Aschner, Michael
Mirzaei, Hamed
author_sort Mahjoubin-Tehran, Maryam
collection PubMed
description Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.
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spelling pubmed-82221902021-08-01 New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs Mahjoubin-Tehran, Maryam Rezaei, Samaneh Jesmani, Amin Birang, Nafise Morshedi, Korosh Khanbabaei, Hashem Khan, Haroon Piranviseh, Ashkan Nejati, Majid Aschner, Michael Mirzaei, Hamed Biomed Pharmacother Article Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke. 2021-05-25 2021-08 /pmc/articles/PMC8222190/ /pubmed/34044272 http://dx.doi.org/10.1016/j.biopha.2021.111753 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Mahjoubin-Tehran, Maryam
Rezaei, Samaneh
Jesmani, Amin
Birang, Nafise
Morshedi, Korosh
Khanbabaei, Hashem
Khan, Haroon
Piranviseh, Ashkan
Nejati, Majid
Aschner, Michael
Mirzaei, Hamed
New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
title New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
title_full New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
title_fullStr New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
title_full_unstemmed New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
title_short New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
title_sort new epigenetic players in stroke pathogenesis: from non-coding rnas to exosomal non-coding rnas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222190/
https://www.ncbi.nlm.nih.gov/pubmed/34044272
http://dx.doi.org/10.1016/j.biopha.2021.111753
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