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Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components
Medial degeneration is a common histopathological finding in aortopathy and is considered a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic thoracic aortic aneurysms versus nondilated aortas. Specimens were graded by pathologists, blinded to the clinical dia...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222259/ https://www.ncbi.nlm.nih.gov/pubmed/34162971 http://dx.doi.org/10.1038/s41598-021-92659-1 |
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author | Yousef, Sameh Matsumoto, Nana Dabe, Issam Mori, Makoto Landry, Alden B. Lee, Shin-Rong Kawamura, Yuki Yang, Chen Li, Guangxin Assi, Roland Vallabhajosyula, Prashanth Geirsson, Arnar Moeckel, Gilbert Humphrey, Jay D. Tellides, George |
author_facet | Yousef, Sameh Matsumoto, Nana Dabe, Issam Mori, Makoto Landry, Alden B. Lee, Shin-Rong Kawamura, Yuki Yang, Chen Li, Guangxin Assi, Roland Vallabhajosyula, Prashanth Geirsson, Arnar Moeckel, Gilbert Humphrey, Jay D. Tellides, George |
author_sort | Yousef, Sameh |
collection | PubMed |
description | Medial degeneration is a common histopathological finding in aortopathy and is considered a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic thoracic aortic aneurysms versus nondilated aortas. Specimens were graded by pathologists, blinded to the clinical diagnosis, according to consensus histopathological criteria. The extent of medial degeneration by qualitative (semi-quantitative) assessment was not specific for aneurysmal compared to nondilated aortas. In contrast, blinded quantitative assessment of elastin amount and medial cell number distinguished aortic aneurysms and referent specimens, albeit with marked overlap in results. Specifically, the medial fraction of elastin decreased from dilution rather than loss of protein as cross-sectional amount was maintained while the cross-sectional number, though not density, of smooth muscle cells increased in proportion to expansion of the media. Furthermore, elastic lamellae did not thin and interlamellar distance did not diminish as expected for lumen dilatation, implying a net gain of lamellar elastin and intralamellar cells or extracellular matrix during aneurysmal wall remodeling. These findings support the concepts that: (1) medial degeneration need not induce aortic aneurysms, (2) adaptive responses to altered mechanical stresses increase medial tissue, and (3) greater turnover, not loss, of mural cells and extracellular matrix associates with aortic dilatation. |
format | Online Article Text |
id | pubmed-8222259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82222592021-06-24 Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components Yousef, Sameh Matsumoto, Nana Dabe, Issam Mori, Makoto Landry, Alden B. Lee, Shin-Rong Kawamura, Yuki Yang, Chen Li, Guangxin Assi, Roland Vallabhajosyula, Prashanth Geirsson, Arnar Moeckel, Gilbert Humphrey, Jay D. Tellides, George Sci Rep Article Medial degeneration is a common histopathological finding in aortopathy and is considered a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic thoracic aortic aneurysms versus nondilated aortas. Specimens were graded by pathologists, blinded to the clinical diagnosis, according to consensus histopathological criteria. The extent of medial degeneration by qualitative (semi-quantitative) assessment was not specific for aneurysmal compared to nondilated aortas. In contrast, blinded quantitative assessment of elastin amount and medial cell number distinguished aortic aneurysms and referent specimens, albeit with marked overlap in results. Specifically, the medial fraction of elastin decreased from dilution rather than loss of protein as cross-sectional amount was maintained while the cross-sectional number, though not density, of smooth muscle cells increased in proportion to expansion of the media. Furthermore, elastic lamellae did not thin and interlamellar distance did not diminish as expected for lumen dilatation, implying a net gain of lamellar elastin and intralamellar cells or extracellular matrix during aneurysmal wall remodeling. These findings support the concepts that: (1) medial degeneration need not induce aortic aneurysms, (2) adaptive responses to altered mechanical stresses increase medial tissue, and (3) greater turnover, not loss, of mural cells and extracellular matrix associates with aortic dilatation. Nature Publishing Group UK 2021-06-23 /pmc/articles/PMC8222259/ /pubmed/34162971 http://dx.doi.org/10.1038/s41598-021-92659-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yousef, Sameh Matsumoto, Nana Dabe, Issam Mori, Makoto Landry, Alden B. Lee, Shin-Rong Kawamura, Yuki Yang, Chen Li, Guangxin Assi, Roland Vallabhajosyula, Prashanth Geirsson, Arnar Moeckel, Gilbert Humphrey, Jay D. Tellides, George Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components |
title | Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components |
title_full | Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components |
title_fullStr | Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components |
title_full_unstemmed | Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components |
title_short | Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components |
title_sort | quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222259/ https://www.ncbi.nlm.nih.gov/pubmed/34162971 http://dx.doi.org/10.1038/s41598-021-92659-1 |
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