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Inhibition of Polo-like kinase 4 induces mitotic defects and DNA damage in diffuse large B-cell lymphoma

Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of chemotherapy. Nevertheless, the role of PLK4 in diffus...

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Detalles Bibliográficos
Autores principales:	Zhao, Yi, Yang, Juan, Liu, Jiarui, Cai, Yiqing, Han, Yang, Hu, Shunfeng, Ren, Shuai, Zhou, Xiangxiang, Wang, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222327/ https://www.ncbi.nlm.nih.gov/pubmed/34162828 http://dx.doi.org/10.1038/s41419-021-03919-x

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