Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance

Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself enhances resistance by progressively changing the cancer cell-intrinsic adhesion...

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Detalles Bibliográficos
Autores principales: Pietilä, Elina A., Gonzalez-Molina, Jordi, Moyano-Galceran, Lidia, Jamalzadeh, Sanaz, Zhang, Kaiyang, Lehtinen, Laura, Turunen, S. Pauliina, Martins, Tomás A., Gultekin, Okan, Lamminen, Tarja, Kaipio, Katja, Joneborg, Ulrika, Hynninen, Johanna, Hietanen, Sakari, Grénman, Seija, Lehtonen, Rainer, Hautaniemi, Sampsa, Carpén, Olli, Carlson, Joseph W., Lehti, Kaisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222388/
https://www.ncbi.nlm.nih.gov/pubmed/34162871
http://dx.doi.org/10.1038/s41467-021-24009-8

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