CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling

The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expression...

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Detalles Bibliográficos
Autores principales: Yu, Shijun, Hu, Qingqing, Fan, Kailing, Yang, Chen, Gao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222461/
https://www.ncbi.nlm.nih.gov/pubmed/33928514
http://dx.doi.org/10.1007/s12079-021-00619-1
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author Yu, Shijun
Hu, Qingqing
Fan, Kailing
Yang, Chen
Gao, Yong
author_facet Yu, Shijun
Hu, Qingqing
Fan, Kailing
Yang, Chen
Gao, Yong
author_sort Yu, Shijun
collection PubMed
description The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expression microarray data from online database and immunohistochemistry analysis demonstrated that CSNK2B was highly expressed in CRC tissues than in normal tissues. In vitro and in vivo cellular functional experiments showed that increased CSNK2B expression promoted CRC cell viability and tumorigenesis of CRC. Further western blots and rescue experiments confirmed that CSNK2B promoted CRC cell proliferation mainly by activating the mTOR signaling pathway. These findings identified CSNK2B as a novel oncogene contributing to the development of CRC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12079-021-00619-1.
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spelling pubmed-82224612021-07-09 CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling Yu, Shijun Hu, Qingqing Fan, Kailing Yang, Chen Gao, Yong J Cell Commun Signal Research Article The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expression microarray data from online database and immunohistochemistry analysis demonstrated that CSNK2B was highly expressed in CRC tissues than in normal tissues. In vitro and in vivo cellular functional experiments showed that increased CSNK2B expression promoted CRC cell viability and tumorigenesis of CRC. Further western blots and rescue experiments confirmed that CSNK2B promoted CRC cell proliferation mainly by activating the mTOR signaling pathway. These findings identified CSNK2B as a novel oncogene contributing to the development of CRC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12079-021-00619-1. Springer Netherlands 2021-04-29 2021-09 /pmc/articles/PMC8222461/ /pubmed/33928514 http://dx.doi.org/10.1007/s12079-021-00619-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Yu, Shijun
Hu, Qingqing
Fan, Kailing
Yang, Chen
Gao, Yong
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
title CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
title_full CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
title_fullStr CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
title_full_unstemmed CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
title_short CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
title_sort csnk2b contributes to colorectal cancer cell proliferation by activating the mtor signaling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222461/
https://www.ncbi.nlm.nih.gov/pubmed/33928514
http://dx.doi.org/10.1007/s12079-021-00619-1
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