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A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells

Renal tubular epithelial-myofibroblast transdifferentiation (EMT) plays a central role in the development of renal interstitial fibrosis (RIF). The profibrotic cytokine interleukin (IL)-1 and the IL-1 receptor (IL-1R) also participate in RIF development, and Toll/IL-1R 8 (TIR8), a member of the Toll...

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Detalles Bibliográficos
Autores principales:	Jiang, Keguo, Zhang, Yuying, He, Fan, Zhang, Mingming, Li, Tianyu, Tu, Zhenzhen, Xu, Deping, Zhang, Min, Han, Linzi, Guo, Liyu, Zhou, Haisheng, Wang, Deguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222463/ https://www.ncbi.nlm.nih.gov/pubmed/33945104 http://dx.doi.org/10.1007/s12079-021-00620-8

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