Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines

An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates co...

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Detalles Bibliográficos
Autores principales: Wan, Junlin, Jiang, Jun, Li, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222546/
https://www.ncbi.nlm.nih.gov/pubmed/34178942
http://dx.doi.org/10.3389/fchem.2021.672704
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author Wan, Junlin
Jiang, Jun
Li, Juan
author_facet Wan, Junlin
Jiang, Jun
Li, Juan
author_sort Wan, Junlin
collection PubMed
description An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates could be evaluated fast via NMR analysis with high accuracy.
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spelling pubmed-82225462021-06-25 Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines Wan, Junlin Jiang, Jun Li, Juan Front Chem Chemistry An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates could be evaluated fast via NMR analysis with high accuracy. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8222546/ /pubmed/34178942 http://dx.doi.org/10.3389/fchem.2021.672704 Text en Copyright © 2021 Wan, Jiang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wan, Junlin
Jiang, Jun
Li, Juan
Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_full Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_fullStr Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_full_unstemmed Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_short Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_sort chiral phosphoric acid promoted chiral 1h nmr analysis of atropisomeric quinolines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222546/
https://www.ncbi.nlm.nih.gov/pubmed/34178942
http://dx.doi.org/10.3389/fchem.2021.672704
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