Involvement of Mast Cells in the Pathophysiology of Pain

Mast cells (MCs) are immune cells and are widely distributed throughout the body. MCs are not only classically viewed as effector cells of some allergic diseases but also participate in host defense, innate and acquired immunity, homeostatic responses, and immunoregulation. Mounting evidence indicat...

Descripción completa

Detalles Bibliográficos
Autores principales: Mai, Lijia, Liu, Qing, Huang, Fang, He, Hongwen, Fan, Wenguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222580/
https://www.ncbi.nlm.nih.gov/pubmed/34177465
http://dx.doi.org/10.3389/fncel.2021.665066
_version_ 1783711513400311808
author Mai, Lijia
Liu, Qing
Huang, Fang
He, Hongwen
Fan, Wenguo
author_facet Mai, Lijia
Liu, Qing
Huang, Fang
He, Hongwen
Fan, Wenguo
author_sort Mai, Lijia
collection PubMed
description Mast cells (MCs) are immune cells and are widely distributed throughout the body. MCs are not only classically viewed as effector cells of some allergic diseases but also participate in host defense, innate and acquired immunity, homeostatic responses, and immunoregulation. Mounting evidence indicates that activation of MCs releasing numerous vasoactive and inflammatory mediators has effects on the nervous system and has been involved in different pain conditions. Here, we review the latest advances made about the implication of MCs in pain. Possible cellular and molecular mechanisms regarding the crosstalk between MC and the nervous system in the initiation and maintenance of pain are also discussed.
format Online
Article
Text
id pubmed-8222580
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82225802021-06-25 Involvement of Mast Cells in the Pathophysiology of Pain Mai, Lijia Liu, Qing Huang, Fang He, Hongwen Fan, Wenguo Front Cell Neurosci Cellular Neuroscience Mast cells (MCs) are immune cells and are widely distributed throughout the body. MCs are not only classically viewed as effector cells of some allergic diseases but also participate in host defense, innate and acquired immunity, homeostatic responses, and immunoregulation. Mounting evidence indicates that activation of MCs releasing numerous vasoactive and inflammatory mediators has effects on the nervous system and has been involved in different pain conditions. Here, we review the latest advances made about the implication of MCs in pain. Possible cellular and molecular mechanisms regarding the crosstalk between MC and the nervous system in the initiation and maintenance of pain are also discussed. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8222580/ /pubmed/34177465 http://dx.doi.org/10.3389/fncel.2021.665066 Text en Copyright © 2021 Mai, Liu, Huang, He and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Mai, Lijia
Liu, Qing
Huang, Fang
He, Hongwen
Fan, Wenguo
Involvement of Mast Cells in the Pathophysiology of Pain
title Involvement of Mast Cells in the Pathophysiology of Pain
title_full Involvement of Mast Cells in the Pathophysiology of Pain
title_fullStr Involvement of Mast Cells in the Pathophysiology of Pain
title_full_unstemmed Involvement of Mast Cells in the Pathophysiology of Pain
title_short Involvement of Mast Cells in the Pathophysiology of Pain
title_sort involvement of mast cells in the pathophysiology of pain
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222580/
https://www.ncbi.nlm.nih.gov/pubmed/34177465
http://dx.doi.org/10.3389/fncel.2021.665066
work_keys_str_mv AT mailijia involvementofmastcellsinthepathophysiologyofpain
AT liuqing involvementofmastcellsinthepathophysiologyofpain
AT huangfang involvementofmastcellsinthepathophysiologyofpain
AT hehongwen involvementofmastcellsinthepathophysiologyofpain
AT fanwenguo involvementofmastcellsinthepathophysiologyofpain

Ejemplares similares