Insights Into the Function and Clinical Application of HDAC5 in Cancer Management

Histone deacetylase 5 (HDAC5) is a class II HDAC. Aberrant expression of HDAC5 has been observed in multiple cancer types, and its functions in cell proliferation and invasion, the immune response, and maintenance of stemness have been widely studied. HDAC5 is considered as a reliable therapeutic ta...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Gong, Chaoju, Ke, Qinjian, Fang, Zejun, Chen, Xiaowen, Ye, Ming, Xu, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222663/
https://www.ncbi.nlm.nih.gov/pubmed/34178647
http://dx.doi.org/10.3389/fonc.2021.661620
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author Yang, Jun
Gong, Chaoju
Ke, Qinjian
Fang, Zejun
Chen, Xiaowen
Ye, Ming
Xu, Xi
author_facet Yang, Jun
Gong, Chaoju
Ke, Qinjian
Fang, Zejun
Chen, Xiaowen
Ye, Ming
Xu, Xi
author_sort Yang, Jun
collection PubMed
description Histone deacetylase 5 (HDAC5) is a class II HDAC. Aberrant expression of HDAC5 has been observed in multiple cancer types, and its functions in cell proliferation and invasion, the immune response, and maintenance of stemness have been widely studied. HDAC5 is considered as a reliable therapeutic target for anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we provide an overview of the expression, biological functions, regulatory mechanisms, and clinical significance of HDAC5 in cancer.
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spelling pubmed-82226632021-06-25 Insights Into the Function and Clinical Application of HDAC5 in Cancer Management Yang, Jun Gong, Chaoju Ke, Qinjian Fang, Zejun Chen, Xiaowen Ye, Ming Xu, Xi Front Oncol Oncology Histone deacetylase 5 (HDAC5) is a class II HDAC. Aberrant expression of HDAC5 has been observed in multiple cancer types, and its functions in cell proliferation and invasion, the immune response, and maintenance of stemness have been widely studied. HDAC5 is considered as a reliable therapeutic target for anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we provide an overview of the expression, biological functions, regulatory mechanisms, and clinical significance of HDAC5 in cancer. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8222663/ /pubmed/34178647 http://dx.doi.org/10.3389/fonc.2021.661620 Text en Copyright © 2021 Yang, Gong, Ke, Fang, Chen, Ye and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Jun
Gong, Chaoju
Ke, Qinjian
Fang, Zejun
Chen, Xiaowen
Ye, Ming
Xu, Xi
Insights Into the Function and Clinical Application of HDAC5 in Cancer Management
title Insights Into the Function and Clinical Application of HDAC5 in Cancer Management
title_full Insights Into the Function and Clinical Application of HDAC5 in Cancer Management
title_fullStr Insights Into the Function and Clinical Application of HDAC5 in Cancer Management
title_full_unstemmed Insights Into the Function and Clinical Application of HDAC5 in Cancer Management
title_short Insights Into the Function and Clinical Application of HDAC5 in Cancer Management
title_sort insights into the function and clinical application of hdac5 in cancer management
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222663/
https://www.ncbi.nlm.nih.gov/pubmed/34178647
http://dx.doi.org/10.3389/fonc.2021.661620
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