More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood

Cells of the skin and circulation are in constant two-way communication. Following exposure of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and function of circulating blood cells. In this review, only data obtained from human studies are considered, with cha...

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Detalles Bibliográficos
Autores principales: Hart, Prue H., Norval, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222718/
https://www.ncbi.nlm.nih.gov/pubmed/34177957
http://dx.doi.org/10.3389/fimmu.2021.694086
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author Hart, Prue H.
Norval, Mary
author_facet Hart, Prue H.
Norval, Mary
author_sort Hart, Prue H.
collection PubMed
description Cells of the skin and circulation are in constant two-way communication. Following exposure of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and function of circulating blood cells. In this review, only data obtained from human studies are considered, with changes induced by UV radiation (UVR) exposure described for phagocytic leukocytes and peripheral blood mononuclear cells plus their component T and B cells, natural killer cells and dendritic cells. These immune modulations illustrate the potential of UVR to have therapeutic effects beyond the skin, and that sunlight exposure is an important environmental influence on human health.
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spelling pubmed-82227182021-06-25 More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood Hart, Prue H. Norval, Mary Front Immunol Immunology Cells of the skin and circulation are in constant two-way communication. Following exposure of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and function of circulating blood cells. In this review, only data obtained from human studies are considered, with changes induced by UV radiation (UVR) exposure described for phagocytic leukocytes and peripheral blood mononuclear cells plus their component T and B cells, natural killer cells and dendritic cells. These immune modulations illustrate the potential of UVR to have therapeutic effects beyond the skin, and that sunlight exposure is an important environmental influence on human health. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8222718/ /pubmed/34177957 http://dx.doi.org/10.3389/fimmu.2021.694086 Text en Copyright © 2021 Hart and Norval https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hart, Prue H.
Norval, Mary
More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood
title More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood
title_full More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood
title_fullStr More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood
title_full_unstemmed More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood
title_short More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood
title_sort more than effects in skin: ultraviolet radiation-induced changes in immune cells in human blood
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222718/
https://www.ncbi.nlm.nih.gov/pubmed/34177957
http://dx.doi.org/10.3389/fimmu.2021.694086
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