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Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons

Neurons exhibit spatial compartmentalization of gene expression where localization of messenger RNAs (mRNAs) to distal processes allows for site-specific distribution of proteins through local translation. Recently, there have been reports of coordination between mRNA transport with vesicular and or...

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Autores principales: Kharod, Shivani C., Hwang, Dong-Woo, Das, Sulagna, Yoon, Young J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222803/
https://www.ncbi.nlm.nih.gov/pubmed/34178987
http://dx.doi.org/10.3389/fcell.2021.663367
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author Kharod, Shivani C.
Hwang, Dong-Woo
Das, Sulagna
Yoon, Young J.
author_facet Kharod, Shivani C.
Hwang, Dong-Woo
Das, Sulagna
Yoon, Young J.
author_sort Kharod, Shivani C.
collection PubMed
description Neurons exhibit spatial compartmentalization of gene expression where localization of messenger RNAs (mRNAs) to distal processes allows for site-specific distribution of proteins through local translation. Recently, there have been reports of coordination between mRNA transport with vesicular and organellar trafficking. In this review, we will highlight the latest literature on axonal and dendritic local protein synthesis with links to mRNA–organelle cotransport followed by emerging technologies necessary to study these phenomena. Recent high-resolution imaging studies have led to insights into the dynamics of RNA–organelle interactions, and we can now peer into these intricate interactions within subcellular compartments of neurons.
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spelling pubmed-82228032021-06-25 Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons Kharod, Shivani C. Hwang, Dong-Woo Das, Sulagna Yoon, Young J. Front Cell Dev Biol Cell and Developmental Biology Neurons exhibit spatial compartmentalization of gene expression where localization of messenger RNAs (mRNAs) to distal processes allows for site-specific distribution of proteins through local translation. Recently, there have been reports of coordination between mRNA transport with vesicular and organellar trafficking. In this review, we will highlight the latest literature on axonal and dendritic local protein synthesis with links to mRNA–organelle cotransport followed by emerging technologies necessary to study these phenomena. Recent high-resolution imaging studies have led to insights into the dynamics of RNA–organelle interactions, and we can now peer into these intricate interactions within subcellular compartments of neurons. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8222803/ /pubmed/34178987 http://dx.doi.org/10.3389/fcell.2021.663367 Text en Copyright © 2021 Kharod, Hwang, Das and Yoon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Kharod, Shivani C.
Hwang, Dong-Woo
Das, Sulagna
Yoon, Young J.
Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons
title Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons
title_full Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons
title_fullStr Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons
title_full_unstemmed Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons
title_short Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons
title_sort spatiotemporal insights into rna–organelle interactions in neurons
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222803/
https://www.ncbi.nlm.nih.gov/pubmed/34178987
http://dx.doi.org/10.3389/fcell.2021.663367
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