Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity

The major histocompatibility complex (MHC) class I (MHC-I) region contains a multitude of genes relevant to immune response. Multiple E3 ubiquitin ligase genes, including tripartite motif 10 (TRIM10), TRIM15, TRIM26, TRIM27, TRIM31, TRIM38, TRIM39, TRIM40, and RING finger protein 39 (RNF39), are org...

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Autores principales: Jia, Xiuzhi, Zhao, Chunyuan, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222901/
https://www.ncbi.nlm.nih.gov/pubmed/34177938
http://dx.doi.org/10.3389/fimmu.2021.687102
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author Jia, Xiuzhi
Zhao, Chunyuan
Zhao, Wei
author_facet Jia, Xiuzhi
Zhao, Chunyuan
Zhao, Wei
author_sort Jia, Xiuzhi
collection PubMed
description The major histocompatibility complex (MHC) class I (MHC-I) region contains a multitude of genes relevant to immune response. Multiple E3 ubiquitin ligase genes, including tripartite motif 10 (TRIM10), TRIM15, TRIM26, TRIM27, TRIM31, TRIM38, TRIM39, TRIM40, and RING finger protein 39 (RNF39), are organized in a tight cluster, and an additional two TRIM genes (namely TRIM38 and TRIM27) telomeric of the cluster within the MHC-I region. The E3 ubiquitin ligases encoded by these genes possess important roles in controlling the intensity of innate immune responses. In this review, we discuss the E3 ubiquitin ligases encoded within the MHC-I region, highlight their regulatory roles in innate immunity, and outline their potential functions in infection, inflammatory and autoimmune diseases.
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spelling pubmed-82229012021-06-25 Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity Jia, Xiuzhi Zhao, Chunyuan Zhao, Wei Front Immunol Immunology The major histocompatibility complex (MHC) class I (MHC-I) region contains a multitude of genes relevant to immune response. Multiple E3 ubiquitin ligase genes, including tripartite motif 10 (TRIM10), TRIM15, TRIM26, TRIM27, TRIM31, TRIM38, TRIM39, TRIM40, and RING finger protein 39 (RNF39), are organized in a tight cluster, and an additional two TRIM genes (namely TRIM38 and TRIM27) telomeric of the cluster within the MHC-I region. The E3 ubiquitin ligases encoded by these genes possess important roles in controlling the intensity of innate immune responses. In this review, we discuss the E3 ubiquitin ligases encoded within the MHC-I region, highlight their regulatory roles in innate immunity, and outline their potential functions in infection, inflammatory and autoimmune diseases. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8222901/ /pubmed/34177938 http://dx.doi.org/10.3389/fimmu.2021.687102 Text en Copyright © 2021 Jia, Zhao and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jia, Xiuzhi
Zhao, Chunyuan
Zhao, Wei
Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity
title Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity
title_full Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity
title_fullStr Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity
title_full_unstemmed Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity
title_short Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity
title_sort emerging roles of mhc class i region-encoded e3 ubiquitin ligases in innate immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222901/
https://www.ncbi.nlm.nih.gov/pubmed/34177938
http://dx.doi.org/10.3389/fimmu.2021.687102
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