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G3BPs in Plant Stress

The sessile nature of plants enforces highly adaptable strategies to adapt to different environmental stresses. Plants respond to these stresses by a massive reprogramming of mRNA metabolism. Balancing of mRNA fates, including translation, sequestration, and decay is essential for plants to not only...

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Autores principales: Abulfaraj, Aala A., Hirt, Heribert, Rayapuram, Naganand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222905/
https://www.ncbi.nlm.nih.gov/pubmed/34177995
http://dx.doi.org/10.3389/fpls.2021.680710
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author Abulfaraj, Aala A.
Hirt, Heribert
Rayapuram, Naganand
author_facet Abulfaraj, Aala A.
Hirt, Heribert
Rayapuram, Naganand
author_sort Abulfaraj, Aala A.
collection PubMed
description The sessile nature of plants enforces highly adaptable strategies to adapt to different environmental stresses. Plants respond to these stresses by a massive reprogramming of mRNA metabolism. Balancing of mRNA fates, including translation, sequestration, and decay is essential for plants to not only coordinate growth and development but also to combat biotic and abiotic environmental stresses. RNA stress granules (SGs) and processing bodies (P bodies) synchronize mRNA metabolism for optimum functioning of an organism. SGs are evolutionarily conserved cytoplasmic localized RNA-protein storage sites that are formed in response to adverse conditions, harboring mostly but not always translationally inactive mRNAs. SGs disassemble and release mRNAs into a translationally active form upon stress relief. RasGAP SH3 domain binding proteins (G3BPs or Rasputins) are “scaffolds” for the assembly and stability of SGs, which coordinate receptor mediated signal transduction with RNA metabolism. The role of G3BPs in the formation of SGs is well established in mammals, but G3BPs in plants are poorly characterized. In this review, we discuss recent findings of the dynamics and functions of plant G3BPs in response to environmental stresses and speculate on possible mechanisms such as transcription and post-translational modifications that might regulate the function of this important family of proteins.
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spelling pubmed-82229052021-06-25 G3BPs in Plant Stress Abulfaraj, Aala A. Hirt, Heribert Rayapuram, Naganand Front Plant Sci Plant Science The sessile nature of plants enforces highly adaptable strategies to adapt to different environmental stresses. Plants respond to these stresses by a massive reprogramming of mRNA metabolism. Balancing of mRNA fates, including translation, sequestration, and decay is essential for plants to not only coordinate growth and development but also to combat biotic and abiotic environmental stresses. RNA stress granules (SGs) and processing bodies (P bodies) synchronize mRNA metabolism for optimum functioning of an organism. SGs are evolutionarily conserved cytoplasmic localized RNA-protein storage sites that are formed in response to adverse conditions, harboring mostly but not always translationally inactive mRNAs. SGs disassemble and release mRNAs into a translationally active form upon stress relief. RasGAP SH3 domain binding proteins (G3BPs or Rasputins) are “scaffolds” for the assembly and stability of SGs, which coordinate receptor mediated signal transduction with RNA metabolism. The role of G3BPs in the formation of SGs is well established in mammals, but G3BPs in plants are poorly characterized. In this review, we discuss recent findings of the dynamics and functions of plant G3BPs in response to environmental stresses and speculate on possible mechanisms such as transcription and post-translational modifications that might regulate the function of this important family of proteins. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8222905/ /pubmed/34177995 http://dx.doi.org/10.3389/fpls.2021.680710 Text en Copyright © 2021 Abulfaraj, Hirt and Rayapuram. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Abulfaraj, Aala A.
Hirt, Heribert
Rayapuram, Naganand
G3BPs in Plant Stress
title G3BPs in Plant Stress
title_full G3BPs in Plant Stress
title_fullStr G3BPs in Plant Stress
title_full_unstemmed G3BPs in Plant Stress
title_short G3BPs in Plant Stress
title_sort g3bps in plant stress
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222905/
https://www.ncbi.nlm.nih.gov/pubmed/34177995
http://dx.doi.org/10.3389/fpls.2021.680710
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