Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Complement factor B (FB) mutant variants are associated with excessive complement activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy and membranoproliferative glomerulonephritis (MPGN). Patients with aHUS are currently treated with eculizumab while the...

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Detalles Bibliográficos
Autores principales: Aradottir, Sigridur Sunna, Kristoffersson, Ann-Charlotte, Roumenina, Lubka T., Bjerre, Anna, Kashioulis, Pavlos, Palsson, Runolfur, Karpman, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222914/
https://www.ncbi.nlm.nih.gov/pubmed/34177949
http://dx.doi.org/10.3389/fimmu.2021.690821

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