Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS‐CoV‐2 and Inhibit Viral Replication

The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti‐virals. We combine in vitro RNA analysis with molecular dynamics simulations to build the first 3D m...

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Detalles Bibliográficos
Autores principales: Melidis, Lazaros, Hill, Harriet J., Coltman, Nicholas J., Davies, Scott P., Winczura, Kinga, Chauhan, Tasha, Craig, James S., Garai, Aditya, Hooper, Catherine A. J., Egan, Ross T., McKeating, Jane A., Hodges, Nikolas J., Stamataki, Zania, Grzechnik, Pawel, Hannon, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222931/
https://www.ncbi.nlm.nih.gov/pubmed/33915014
http://dx.doi.org/10.1002/anie.202104179

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