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Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression
BACKGROUND: Problems with impulsive aggression occur in many forms of psychiatric dysfunction, and are a common complaint among combat veterans. The present study sought to examine the neuroanatomical correlates of combat-related impulsive aggression. METHODS: T1-weighted magnetic resonance images w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223237/ https://www.ncbi.nlm.nih.gov/pubmed/32029023 http://dx.doi.org/10.1017/S0033291720000033 |
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author | Varkevisser, Tim van Lutterveld, Remko Heesink, Lieke van Honk, Jack Geuze, Elbert |
author_facet | Varkevisser, Tim van Lutterveld, Remko Heesink, Lieke van Honk, Jack Geuze, Elbert |
author_sort | Varkevisser, Tim |
collection | PubMed |
description | BACKGROUND: Problems with impulsive aggression occur in many forms of psychiatric dysfunction, and are a common complaint among combat veterans. The present study sought to examine the neuroanatomical correlates of combat-related impulsive aggression. METHODS: T1-weighted magnetic resonance images were acquired from 29 male veterans with impulsive aggression and 30 non-aggressive combat controls. Subcortical volumetry was conducted with the amygdala and hippocampus and their main constituent subdivisions as regions-of-interest (ROIs) (basolateral, centromedial amygdala; head, body, tail of hippocampus). Cortical thickness measurements were extracted for the dorsolateral prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex. Within-group correlations with psychometric measures were also explored. RESULTS: No significant group differences in cortical thickness or subcortical grey matter volumes were observed for any of the ROIs. Also, no significant correlations with any of the psychometric measures were recorded. Exploratory whole-brain analysis of cortical thickness revealed a significant group × anxiety interaction effect in a cluster located in the left lingual gyrus. CONCLUSIONS: The current findings indicate that problems with impulsive aggression may not be directly associated with alterations in cortical thickness or amygdalar/hippocampal (sub)volumes. The observed interplay between impulsive aggression problems and anxiety-related symptoms is consistent with prior work showing the two phenomena may share the same underlying (neural) mechanisms. |
format | Online Article Text |
id | pubmed-8223237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82232372021-07-01 Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression Varkevisser, Tim van Lutterveld, Remko Heesink, Lieke van Honk, Jack Geuze, Elbert Psychol Med Original Articles BACKGROUND: Problems with impulsive aggression occur in many forms of psychiatric dysfunction, and are a common complaint among combat veterans. The present study sought to examine the neuroanatomical correlates of combat-related impulsive aggression. METHODS: T1-weighted magnetic resonance images were acquired from 29 male veterans with impulsive aggression and 30 non-aggressive combat controls. Subcortical volumetry was conducted with the amygdala and hippocampus and their main constituent subdivisions as regions-of-interest (ROIs) (basolateral, centromedial amygdala; head, body, tail of hippocampus). Cortical thickness measurements were extracted for the dorsolateral prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex. Within-group correlations with psychometric measures were also explored. RESULTS: No significant group differences in cortical thickness or subcortical grey matter volumes were observed for any of the ROIs. Also, no significant correlations with any of the psychometric measures were recorded. Exploratory whole-brain analysis of cortical thickness revealed a significant group × anxiety interaction effect in a cluster located in the left lingual gyrus. CONCLUSIONS: The current findings indicate that problems with impulsive aggression may not be directly associated with alterations in cortical thickness or amygdalar/hippocampal (sub)volumes. The observed interplay between impulsive aggression problems and anxiety-related symptoms is consistent with prior work showing the two phenomena may share the same underlying (neural) mechanisms. Cambridge University Press 2021-06 2020-02-07 /pmc/articles/PMC8223237/ /pubmed/32029023 http://dx.doi.org/10.1017/S0033291720000033 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work. |
spellingShingle | Original Articles Varkevisser, Tim van Lutterveld, Remko Heesink, Lieke van Honk, Jack Geuze, Elbert Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression |
title | Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression |
title_full | Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression |
title_fullStr | Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression |
title_full_unstemmed | Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression |
title_short | Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression |
title_sort | voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223237/ https://www.ncbi.nlm.nih.gov/pubmed/32029023 http://dx.doi.org/10.1017/S0033291720000033 |
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