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Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing
OBJECTIVE: To analyze trends in cancer incidence and mortality (France, 1990–2018), with a focus on men-women disparities. METHODS: Incidence data stemmed from cancer registries (FRANCIM) and mortality data from national statistics (CépiDc). Incidence and mortality rates were modelled using bidimens...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223369/ https://www.ncbi.nlm.nih.gov/pubmed/34167516 http://dx.doi.org/10.1186/s12885-021-08261-1 |
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author | Defossez, G. Uhry, Z. Delafosse, P. Dantony, E. d’Almeida, T. Plouvier, S. Bossard, N. Bouvier, A. M. Molinié, F. Woronoff, A. S. Colonna, M. Grosclaude, P. Remontet, L. Monnereau, A. |
author_facet | Defossez, G. Uhry, Z. Delafosse, P. Dantony, E. d’Almeida, T. Plouvier, S. Bossard, N. Bouvier, A. M. Molinié, F. Woronoff, A. S. Colonna, M. Grosclaude, P. Remontet, L. Monnereau, A. |
author_sort | Defossez, G. |
collection | PubMed |
description | OBJECTIVE: To analyze trends in cancer incidence and mortality (France, 1990–2018), with a focus on men-women disparities. METHODS: Incidence data stemmed from cancer registries (FRANCIM) and mortality data from national statistics (CépiDc). Incidence and mortality rates were modelled using bidimensional penalized splines of age and year (at diagnosis and at death, respectively). Trends in age-standardized rates were summarized by the average annual percent changes (AAPC) for all-cancers combined, 19 solid tumors, and 8 subsites. Sex gaps were indicated using male-to-female rate ratios (relative difference) and male-to-female rate differences (absolute difference) in 1990 and 2018, for incidence and mortality, respectively. RESULTS: For all-cancers, the sex gap narrowed over 1990–2018 in incidence (1.6 to 1.2) and mortality (2.3 to 1.7). The largest decreases of the male-to-female incidence rate ratio were for cancers of the lung (9.5 to 2.2), lip - oral cavity - pharynx (10.9 to 3.1), esophagus (12.6 to 4.5) and larynx (17.1 to 7.1). Mixed trends emerged in lung and oesophageal cancers, probably explained by differing risk factors for the two main histological subtypes. Sex incidence gaps narrowed due to increasing trends in men and women for skin melanoma (0.7 to 1, due to initially higher rates in women), cancers of the liver (7.4 to 4.4) and pancreas (2.0 to 1.4). Sex incidence gaps narrowed for colon-rectum (1.7 to 1.4), urinary bladder (6.9 to 6.1) and stomach (2.7 to 2.4) driven by decreasing trends among men. Other cancers showed similar increasing incidence trends in both sexes leading to stable sex gaps: thyroid gland (0.3 to 0.3), kidney (2.2 to 2.4) and central nervous system (1.4 to 1.5). CONCLUSION: In France in 2018, while men still had higher risks of developing or dying from most cancers, the sex gap was narrowing. Efforts should focus on avoiding risk factors (e.g., smoking) and developing etiological studies to understand currently unexplained increasing trends. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08261-1. |
format | Online Article Text |
id | pubmed-8223369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82233692021-06-24 Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing Defossez, G. Uhry, Z. Delafosse, P. Dantony, E. d’Almeida, T. Plouvier, S. Bossard, N. Bouvier, A. M. Molinié, F. Woronoff, A. S. Colonna, M. Grosclaude, P. Remontet, L. Monnereau, A. BMC Cancer Research OBJECTIVE: To analyze trends in cancer incidence and mortality (France, 1990–2018), with a focus on men-women disparities. METHODS: Incidence data stemmed from cancer registries (FRANCIM) and mortality data from national statistics (CépiDc). Incidence and mortality rates were modelled using bidimensional penalized splines of age and year (at diagnosis and at death, respectively). Trends in age-standardized rates were summarized by the average annual percent changes (AAPC) for all-cancers combined, 19 solid tumors, and 8 subsites. Sex gaps were indicated using male-to-female rate ratios (relative difference) and male-to-female rate differences (absolute difference) in 1990 and 2018, for incidence and mortality, respectively. RESULTS: For all-cancers, the sex gap narrowed over 1990–2018 in incidence (1.6 to 1.2) and mortality (2.3 to 1.7). The largest decreases of the male-to-female incidence rate ratio were for cancers of the lung (9.5 to 2.2), lip - oral cavity - pharynx (10.9 to 3.1), esophagus (12.6 to 4.5) and larynx (17.1 to 7.1). Mixed trends emerged in lung and oesophageal cancers, probably explained by differing risk factors for the two main histological subtypes. Sex incidence gaps narrowed due to increasing trends in men and women for skin melanoma (0.7 to 1, due to initially higher rates in women), cancers of the liver (7.4 to 4.4) and pancreas (2.0 to 1.4). Sex incidence gaps narrowed for colon-rectum (1.7 to 1.4), urinary bladder (6.9 to 6.1) and stomach (2.7 to 2.4) driven by decreasing trends among men. Other cancers showed similar increasing incidence trends in both sexes leading to stable sex gaps: thyroid gland (0.3 to 0.3), kidney (2.2 to 2.4) and central nervous system (1.4 to 1.5). CONCLUSION: In France in 2018, while men still had higher risks of developing or dying from most cancers, the sex gap was narrowing. Efforts should focus on avoiding risk factors (e.g., smoking) and developing etiological studies to understand currently unexplained increasing trends. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08261-1. BioMed Central 2021-06-24 /pmc/articles/PMC8223369/ /pubmed/34167516 http://dx.doi.org/10.1186/s12885-021-08261-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Defossez, G. Uhry, Z. Delafosse, P. Dantony, E. d’Almeida, T. Plouvier, S. Bossard, N. Bouvier, A. M. Molinié, F. Woronoff, A. S. Colonna, M. Grosclaude, P. Remontet, L. Monnereau, A. Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing |
title | Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing |
title_full | Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing |
title_fullStr | Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing |
title_full_unstemmed | Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing |
title_short | Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing |
title_sort | cancer incidence and mortality trends in france over 1990–2018 for solid tumors: the sex gap is narrowing |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223369/ https://www.ncbi.nlm.nih.gov/pubmed/34167516 http://dx.doi.org/10.1186/s12885-021-08261-1 |
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