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Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks

BACKGROUND: Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response. METHODS: Using network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level inflammatory mediators over 0–48 h in the heart, gut, lun...

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Detalles Bibliográficos
Autores principales:	Zamora, Ruben, Chavan, Sangeeta, Zanos, Theodoros, Simmons, Richard L., Billiar, Timothy R., Vodovotz, Yoram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223370/ https://www.ncbi.nlm.nih.gov/pubmed/34167455 http://dx.doi.org/10.1186/s10020-021-00333-z

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