Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines

[Image: see text] Herein, the antiproliferative effect of surface-decorated gold nanorods (GNRs) was investigated against three different breast cancer cell lines. The results indicate that the cell lines exhibited different biological responses and death modalities toward the treatment. The cell li...

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Autores principales: Abu-Dahab, Rana, Mahmoud, Nouf N., Abdallah, Maha, Hamadneh, Lama, Hikmat, Suhair, Zaza, Rand, Abuarqoub, Duaa, Khalil, Enam A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223419/
https://www.ncbi.nlm.nih.gov/pubmed/34179634
http://dx.doi.org/10.1021/acsomega.1c01386
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author Abu-Dahab, Rana
Mahmoud, Nouf N.
Abdallah, Maha
Hamadneh, Lama
Hikmat, Suhair
Zaza, Rand
Abuarqoub, Duaa
Khalil, Enam A.
author_facet Abu-Dahab, Rana
Mahmoud, Nouf N.
Abdallah, Maha
Hamadneh, Lama
Hikmat, Suhair
Zaza, Rand
Abuarqoub, Duaa
Khalil, Enam A.
author_sort Abu-Dahab, Rana
collection PubMed
description [Image: see text] Herein, the antiproliferative effect of surface-decorated gold nanorods (GNRs) was investigated against three different breast cancer cell lines. The results indicate that the cell lines exhibited different biological responses and death modalities toward the treatment. The cell lines exhibited similar cellular uptake of the nanoparticles; however, MDA-MB-231 demonstrated the highest cytotoxicity compared to other cell lines upon treatment with GNRs. The expression of the CDH1 gene, which is involved in cell adhesion and metastasis, was dramatically increased in treated MDA-MB-231 cells compared to other cell lines. Early apoptosis and late apoptosis are the dominant cellular death modalities of MDA-MB-231 cells upon treatment with GNRs.
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spelling pubmed-82234192021-06-25 Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines Abu-Dahab, Rana Mahmoud, Nouf N. Abdallah, Maha Hamadneh, Lama Hikmat, Suhair Zaza, Rand Abuarqoub, Duaa Khalil, Enam A. ACS Omega [Image: see text] Herein, the antiproliferative effect of surface-decorated gold nanorods (GNRs) was investigated against three different breast cancer cell lines. The results indicate that the cell lines exhibited different biological responses and death modalities toward the treatment. The cell lines exhibited similar cellular uptake of the nanoparticles; however, MDA-MB-231 demonstrated the highest cytotoxicity compared to other cell lines upon treatment with GNRs. The expression of the CDH1 gene, which is involved in cell adhesion and metastasis, was dramatically increased in treated MDA-MB-231 cells compared to other cell lines. Early apoptosis and late apoptosis are the dominant cellular death modalities of MDA-MB-231 cells upon treatment with GNRs. American Chemical Society 2021-06-11 /pmc/articles/PMC8223419/ /pubmed/34179634 http://dx.doi.org/10.1021/acsomega.1c01386 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Abu-Dahab, Rana
Mahmoud, Nouf N.
Abdallah, Maha
Hamadneh, Lama
Hikmat, Suhair
Zaza, Rand
Abuarqoub, Duaa
Khalil, Enam A.
Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
title Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
title_full Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
title_fullStr Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
title_full_unstemmed Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
title_short Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
title_sort cytotoxicity and cellular death modality of surface-decorated gold nanorods against a panel of breast cancer cell lines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223419/
https://www.ncbi.nlm.nih.gov/pubmed/34179634
http://dx.doi.org/10.1021/acsomega.1c01386
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