Cargando…

HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators

[Image: see text] The N6-methyladenosine (m(6)A) modifications in both viral and host cell RNAs play an important role in HIV-1 virus genome transcription and virus replication. We demonstrate here that activators of the METTL3/METTL14/WTAP RNA methyltransferase complex enhance the production of vir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Selberg, Simona, Žusinaite, Eva, Herodes, Koit, Seli, Neinar, Kankuri, Esko, Merits, Andres, Karelson, Mati
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223420/ https://www.ncbi.nlm.nih.gov/pubmed/34179640 http://dx.doi.org/10.1021/acsomega.1c01626

Ejemplares similares

Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors
por: Selberg, Simona, et al.
Publicado: (2021)

Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons
por: Selberg, Simona, et al.
Publicado: (2021)

Interactions, localization, and phosphorylation of the m(6)A generating METTL3–METTL14–WTAP complex
por: Schöller, Eva, et al.
Publicado: (2018)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis
por: Kobayashi, Masatoshi, et al.
Publicado: (2018)

METTL3 regulates WTAP protein homeostasis
por: Sorci, Melissa, et al.
Publicado: (2018)

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression
por: Yan, Chaojun, et al.
Publicado: (2023)

WTAP–VIRMA counteracts dsDNA binding of the m(6)A writer METTL3–METTL14 complex and maintains N(6)-adenosine methylation activity
por: Yan, Xuhui, et al.
Publicado: (2023)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

Analysis of METTL3 and METTL14 in hepatocellular carcinoma
por: Liu, Xiangxiang, et al.
Publicado: (2020)

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus
por: Zhao, Lingcai, et al.
Publicado: (2022)

Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

Targeting METTL14 and RNA methylation to treat osteosarcoma
por: Ren, Lili, et al.
Publicado: (2022)

A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
por: Liu, Jianzhao, et al.
Publicado: (2013)

RNA binding to human METTL3-METTL14 restricts N(6)-deoxyadenosine methylation of DNA in vitro
por: Qi, Shan, et al.
Publicado: (2022)

Correction: Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors
por: Ivanova, Larisa, et al.
Publicado: (2021)

METTL14-mediated RNA methylation in digestive system tumors
por: Hu, Jiexuan, et al.
Publicado: (2023)

Insights into roles of METTL14 in tumors
por: Liu, Xin, et al.
Publicado: (2021)

The Comprehensive Analysis of N6-Methyadenosine Writer METTL3 and METTL14 in Gastric Cancer
por: Ge, Yiling, et al.
Publicado: (2023)

Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP
por: Gao, Yan, et al.
Publicado: (2023)

PRMT1 methylates METTL14 to modulate its oncogenic function
por: Wang, Jingchao, et al.
Publicado: (2023)

Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
por: Huang, Jinbo, et al.
Publicado: (2018)

A cryptic pocket in METTL3-METTL14 regulates m(6)A conversion and sensing
por: Qi, Shan, et al.
Publicado: (2023)

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications
por: Mutso, Margit, et al.
Publicado: (2015)

The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1‐positive acute lymphoblastic leukemia
por: Sun, Congcong, et al.
Publicado: (2019)

Opposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13
por: Parker, Haley V., et al.
Publicado: (2023)

m(6)A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype
por: Liu, Pingyu, et al.
Publicado: (2021)

METTL3/METTL14 Transactivation and m(6)A-Dependent TGF-β1 Translation in Activated Kupffer Cells
por: Feng, Yue, et al.
Publicado: (2021)

Oxford on Its Mettle
Publicado: (1891)

Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
por: Guan, Qian, et al.
Publicado: (2022)

Knockdown of METTL14 inhibits the growth and invasion of cervical cancer
por: Geng, Feng, et al.
Publicado: (2019)

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
por: Yu, Dan, et al.
Publicado: (2021)

Novel Analogues of the Chikungunya Virus Protease Inhibitor: Molecular Design, Synthesis, and Biological Evaluation
por: Ivanova, Larisa, et al.
Publicado: (2021)

Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing’s sarcoma
por: Jiang, Jie, et al.
Publicado: (2022)

The emerging importance of METTL5-mediated ribosomal RNA methylation
por: Turkalj, Elena M., et al.
Publicado: (2022)

7SK methylation by METTL3 promotes transcriptional activity
por: Perez-Pepe, Marcelo, et al.
Publicado: (2023)

Localization of METTL16 at the Nuclear Periphery and the Nucleolus Is Cell Cycle-Specific and METTL16 Interacts with Several Nucleolar Proteins
por: Stixová, Lenka, et al.
Publicado: (2021)

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis
por: Lang, Fengchao, et al.
Publicado: (2019)

The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
por: Shi, Bin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_372l9ik303hkgaqhk44f44qqra