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Landscape-Based Mutational Sensitivity Cartography and Network Community Analysis of the SARS-CoV-2 Spike Protein Structures: Quantifying Functional Effects of the Circulating D614G Variant

[Image: see text] We developed and applied a computational approach to simulate functional effects of the global circulating mutation D614G of the SARS-CoV-2 spike protein. All-atom molecular dynamics simulations are combined with deep mutational scanning and analysis of the residue interaction netw...

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Detalles Bibliográficos
Autores principales:	Verkhivker, Gennady M., Agajanian, Steve, Oztas, Deniz Yasar, Gupta, Grace
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223427/ https://www.ncbi.nlm.nih.gov/pubmed/34179666 http://dx.doi.org/10.1021/acsomega.1c02336

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