Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides

[Image: see text] In the absence of ligand, Cs(2)CO(3)-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans res...

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Detalles Bibliográficos
Autores principales: Iqbal, Muhammad Asif, Lu, Le, Mehmood, Hina, Hua, Ruimao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223439/
https://www.ncbi.nlm.nih.gov/pubmed/34179643
http://dx.doi.org/10.1021/acsomega.1c01736
Descripción
Sumario:[Image: see text] In the absence of ligand, Cs(2)CO(3)-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans resulting from the reactions between arenes and 1-bromo-2-iodobenzene is also reported. On the basis of control experiments and theoretical studies, a radical mechanism is proposed for the formation of biaryls.

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