Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides

[Image: see text] In the absence of ligand, Cs(2)CO(3)-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans res...

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Autores principales: Iqbal, Muhammad Asif, Lu, Le, Mehmood, Hina, Hua, Ruimao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223439/
https://www.ncbi.nlm.nih.gov/pubmed/34179643
http://dx.doi.org/10.1021/acsomega.1c01736
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author Iqbal, Muhammad Asif
Lu, Le
Mehmood, Hina
Hua, Ruimao
author_facet Iqbal, Muhammad Asif
Lu, Le
Mehmood, Hina
Hua, Ruimao
author_sort Iqbal, Muhammad Asif
collection PubMed
description [Image: see text] In the absence of ligand, Cs(2)CO(3)-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans resulting from the reactions between arenes and 1-bromo-2-iodobenzene is also reported. On the basis of control experiments and theoretical studies, a radical mechanism is proposed for the formation of biaryls.
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spelling pubmed-82234392021-06-25 Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides Iqbal, Muhammad Asif Lu, Le Mehmood, Hina Hua, Ruimao ACS Omega [Image: see text] In the absence of ligand, Cs(2)CO(3)-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans resulting from the reactions between arenes and 1-bromo-2-iodobenzene is also reported. On the basis of control experiments and theoretical studies, a radical mechanism is proposed for the formation of biaryls. American Chemical Society 2021-06-09 /pmc/articles/PMC8223439/ /pubmed/34179643 http://dx.doi.org/10.1021/acsomega.1c01736 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Iqbal, Muhammad Asif
Lu, Le
Mehmood, Hina
Hua, Ruimao
Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
title Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
title_full Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
title_fullStr Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
title_full_unstemmed Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
title_short Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
title_sort biaryl formation via base-promoted direct coupling reactions of arenes with aryl halides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223439/
https://www.ncbi.nlm.nih.gov/pubmed/34179643
http://dx.doi.org/10.1021/acsomega.1c01736
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