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An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the vulnerability of human populations to novel viral pressures, despite the vast array of epidemiological and biomedical tools now available. Notably, modern human genomes contain evolutionary informati...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223470/ https://www.ncbi.nlm.nih.gov/pubmed/34171302 http://dx.doi.org/10.1016/j.cub.2021.05.067 |
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author | Souilmi, Yassine Lauterbur, M. Elise Tobler, Ray Huber, Christian D. Johar, Angad S. Moradi, Shayli Varasteh Johnston, Wayne A. Krogan, Nevan J. Alexandrov, Kirill Enard, David |
author_facet | Souilmi, Yassine Lauterbur, M. Elise Tobler, Ray Huber, Christian D. Johar, Angad S. Moradi, Shayli Varasteh Johnston, Wayne A. Krogan, Nevan J. Alexandrov, Kirill Enard, David |
author_sort | Souilmi, Yassine |
collection | PubMed |
description | The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the vulnerability of human populations to novel viral pressures, despite the vast array of epidemiological and biomedical tools now available. Notably, modern human genomes contain evolutionary information tracing back tens of thousands of years, which may help identify the viruses that have impacted our ancestors—pointing to which viruses have future pandemic potential. Here, we apply evolutionary analyses to human genomic datasets to recover selection events involving tens of human genes that interact with coronaviruses, including SARS-CoV-2, that likely started more than 20,000 years ago. These adaptive events were limited to the population ancestral to East Asian populations. Multiple lines of functional evidence support an ancient viral selective pressure, and East Asia is the geographical origin of several modern coronavirus epidemics. An arms race with an ancient coronavirus, or with a different virus that happened to use similar interactions as coronaviruses with human hosts, may thus have taken place in ancestral East Asian populations. By learning more about our ancient viral foes, our study highlights the promise of evolutionary information to better predict the pandemics of the future. Importantly, adaptation to ancient viral epidemics in specific human populations does not necessarily imply any difference in genetic susceptibility between different human populations, and the current evidence points toward an overwhelming impact of socioeconomic factors in the case of coronavirus disease 2019 (COVID-19). |
format | Online Article Text |
id | pubmed-8223470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82234702021-06-25 An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia Souilmi, Yassine Lauterbur, M. Elise Tobler, Ray Huber, Christian D. Johar, Angad S. Moradi, Shayli Varasteh Johnston, Wayne A. Krogan, Nevan J. Alexandrov, Kirill Enard, David Curr Biol Article The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the vulnerability of human populations to novel viral pressures, despite the vast array of epidemiological and biomedical tools now available. Notably, modern human genomes contain evolutionary information tracing back tens of thousands of years, which may help identify the viruses that have impacted our ancestors—pointing to which viruses have future pandemic potential. Here, we apply evolutionary analyses to human genomic datasets to recover selection events involving tens of human genes that interact with coronaviruses, including SARS-CoV-2, that likely started more than 20,000 years ago. These adaptive events were limited to the population ancestral to East Asian populations. Multiple lines of functional evidence support an ancient viral selective pressure, and East Asia is the geographical origin of several modern coronavirus epidemics. An arms race with an ancient coronavirus, or with a different virus that happened to use similar interactions as coronaviruses with human hosts, may thus have taken place in ancestral East Asian populations. By learning more about our ancient viral foes, our study highlights the promise of evolutionary information to better predict the pandemics of the future. Importantly, adaptation to ancient viral epidemics in specific human populations does not necessarily imply any difference in genetic susceptibility between different human populations, and the current evidence points toward an overwhelming impact of socioeconomic factors in the case of coronavirus disease 2019 (COVID-19). The Authors. Published by Elsevier Inc. 2021-08-23 2021-06-24 /pmc/articles/PMC8223470/ /pubmed/34171302 http://dx.doi.org/10.1016/j.cub.2021.05.067 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Souilmi, Yassine Lauterbur, M. Elise Tobler, Ray Huber, Christian D. Johar, Angad S. Moradi, Shayli Varasteh Johnston, Wayne A. Krogan, Nevan J. Alexandrov, Kirill Enard, David An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia |
title | An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia |
title_full | An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia |
title_fullStr | An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia |
title_full_unstemmed | An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia |
title_short | An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia |
title_sort | ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in east asia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223470/ https://www.ncbi.nlm.nih.gov/pubmed/34171302 http://dx.doi.org/10.1016/j.cub.2021.05.067 |
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