Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

There is widespread interest in facile methods for generating potent neutralizing antibodies, nanobodies, and other affinity proteins against SARS-CoV-2 and related viruses to address current and future pandemics. While isolating antibodies from animals and humans are proven approaches, these method...

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Detalles Bibliográficos
Autores principales: Zupancic, Jennifer M., Desai, Alec A., Schardt, John S., Pornnoppadol, Ghasidit, Makowski, Emily K., Smith, Matthew D., Kennedy, Andrew A., Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Tai, Andrew W., Tessier, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223476/
https://www.ncbi.nlm.nih.gov/pubmed/34171229
http://dx.doi.org/10.1016/j.chembiol.2021.05.019

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