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Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

2-Oxoglutarate (2OG) oxygenases have important roles in human biology and are validated medicinal chemistry targets. Improving the selectivity profile of broad-spectrum 2OG oxygenase inhibitors may help enable the identification of selective inhibitors for use in functional assignment work. We repor...

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Detalles Bibliográficos
Autores principales:	Brewitz, Lennart, Nakashima, Yu, Tumber, Anthony, Salah, Eidarus, Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Sequoia Sa 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223498/ https://www.ncbi.nlm.nih.gov/pubmed/34219804 http://dx.doi.org/10.1016/j.jfluchem.2021.109804

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