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Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge

The close phylogenetic relationship between humans and other primates creates exceptionally high potential for pathogen exchange. The surveillance of pathogens in primates plays an important role in anticipating possible outbreaks. In this study, we conducted a molecular investigation of pathogenic...

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Autores principales: Medkour, Hacène, Amona, Inestin, Akiana, Jean, Laidoudi, Younes, Davoust, Bernard, Bitam, Idir, Lafri, Ismail, Levasseur, Anthony, Diatta, Georges, Sokhna, Cheikh, Hernandez-Aguilar, R. Adriana, Barciela, Amanda, Gorsane, Slim, Banga-Mboko, Henri, Raoult, Didier, Fenollar, Florence, Mediannikov, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: YJBM 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223552/
https://www.ncbi.nlm.nih.gov/pubmed/34211344
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author Medkour, Hacène
Amona, Inestin
Akiana, Jean
Laidoudi, Younes
Davoust, Bernard
Bitam, Idir
Lafri, Ismail
Levasseur, Anthony
Diatta, Georges
Sokhna, Cheikh
Hernandez-Aguilar, R. Adriana
Barciela, Amanda
Gorsane, Slim
Banga-Mboko, Henri
Raoult, Didier
Fenollar, Florence
Mediannikov, Oleg
author_facet Medkour, Hacène
Amona, Inestin
Akiana, Jean
Laidoudi, Younes
Davoust, Bernard
Bitam, Idir
Lafri, Ismail
Levasseur, Anthony
Diatta, Georges
Sokhna, Cheikh
Hernandez-Aguilar, R. Adriana
Barciela, Amanda
Gorsane, Slim
Banga-Mboko, Henri
Raoult, Didier
Fenollar, Florence
Mediannikov, Oleg
author_sort Medkour, Hacène
collection PubMed
description The close phylogenetic relationship between humans and other primates creates exceptionally high potential for pathogen exchange. The surveillance of pathogens in primates plays an important role in anticipating possible outbreaks. In this study, we conducted a molecular investigation of pathogenic bacteria in feces from African nonhuman primates (NHPs). We also investigated the pathogens shared by the human population and gorillas living in the same territory in the Republic of Congo. In total, 93% of NHPs (n=176) and 95% (n=38) of humans were found to carry at least one bacterium. Non-pallidum Treponema spp. (including T. succinifaciens, T. berlinense, and several potential new species) were recovered from stools of 70% of great apes, 88% of monkeys, and 79% of humans. Non-tuberculosis Mycobacterium spp. were also common in almost all NHP species as well as in humans. In addition, Acinetobacter spp., members of the primate gut microbiota, were mainly prevalent in human and gorilla. Pathogenic Leptospira spp. were highly present in humans (82%) and gorillas (66%) stool samples in Congo, but were absent in the other NHPs, therefore suggesting a possible gorillas-humans exchange. Particular attention will be necessary for enteropathogenic bacteria detected in humans such as Helicobacter pylori, Salmonella spp. (including S. typhi/paratyphi), Staphyloccocus aureus, and Tropheryma whipplei, some of which were also present in gorillas in the same territory (S. aureus and T. whipplei). This study enhances our knowledge of pathogenic bacteria that threaten African NHPs and humans by using a non-invasive sampling technique. Contact between humans and NHPs results in an exchange of pathogens. Ongoing surveillance, prevention, and treatment strategies alone will limit the spread of these infectious agents.
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spelling pubmed-82235522021-06-30 Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge Medkour, Hacène Amona, Inestin Akiana, Jean Laidoudi, Younes Davoust, Bernard Bitam, Idir Lafri, Ismail Levasseur, Anthony Diatta, Georges Sokhna, Cheikh Hernandez-Aguilar, R. Adriana Barciela, Amanda Gorsane, Slim Banga-Mboko, Henri Raoult, Didier Fenollar, Florence Mediannikov, Oleg Yale J Biol Med Original Contribution The close phylogenetic relationship between humans and other primates creates exceptionally high potential for pathogen exchange. The surveillance of pathogens in primates plays an important role in anticipating possible outbreaks. In this study, we conducted a molecular investigation of pathogenic bacteria in feces from African nonhuman primates (NHPs). We also investigated the pathogens shared by the human population and gorillas living in the same territory in the Republic of Congo. In total, 93% of NHPs (n=176) and 95% (n=38) of humans were found to carry at least one bacterium. Non-pallidum Treponema spp. (including T. succinifaciens, T. berlinense, and several potential new species) were recovered from stools of 70% of great apes, 88% of monkeys, and 79% of humans. Non-tuberculosis Mycobacterium spp. were also common in almost all NHP species as well as in humans. In addition, Acinetobacter spp., members of the primate gut microbiota, were mainly prevalent in human and gorilla. Pathogenic Leptospira spp. were highly present in humans (82%) and gorillas (66%) stool samples in Congo, but were absent in the other NHPs, therefore suggesting a possible gorillas-humans exchange. Particular attention will be necessary for enteropathogenic bacteria detected in humans such as Helicobacter pylori, Salmonella spp. (including S. typhi/paratyphi), Staphyloccocus aureus, and Tropheryma whipplei, some of which were also present in gorillas in the same territory (S. aureus and T. whipplei). This study enhances our knowledge of pathogenic bacteria that threaten African NHPs and humans by using a non-invasive sampling technique. Contact between humans and NHPs results in an exchange of pathogens. Ongoing surveillance, prevention, and treatment strategies alone will limit the spread of these infectious agents. YJBM 2021-06-30 /pmc/articles/PMC8223552/ /pubmed/34211344 Text en Copyright ©2021, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes.
spellingShingle Original Contribution
Medkour, Hacène
Amona, Inestin
Akiana, Jean
Laidoudi, Younes
Davoust, Bernard
Bitam, Idir
Lafri, Ismail
Levasseur, Anthony
Diatta, Georges
Sokhna, Cheikh
Hernandez-Aguilar, R. Adriana
Barciela, Amanda
Gorsane, Slim
Banga-Mboko, Henri
Raoult, Didier
Fenollar, Florence
Mediannikov, Oleg
Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge
title Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge
title_full Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge
title_fullStr Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge
title_full_unstemmed Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge
title_short Bacterial Infections in Humans and Nonhuman Primates from Africa: Expanding the Knowledge
title_sort bacterial infections in humans and nonhuman primates from africa: expanding the knowledge
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223552/
https://www.ncbi.nlm.nih.gov/pubmed/34211344
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