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Niche-specific functional heterogeneity of intestinal resident macrophages

Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the response to food antigens and bacteria that are able to penetrate the mucosal barrier. However, recent advances in sin...

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Autores principales: Viola, Maria Francesca, Boeckxstaens, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223647/
https://www.ncbi.nlm.nih.gov/pubmed/33384336
http://dx.doi.org/10.1136/gutjnl-2020-323121
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author Viola, Maria Francesca
Boeckxstaens, Guy
author_facet Viola, Maria Francesca
Boeckxstaens, Guy
author_sort Viola, Maria Francesca
collection PubMed
description Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the response to food antigens and bacteria that are able to penetrate the mucosal barrier. However, recent advances in single-cell RNA sequencing technology have revealed that resident macrophages throughout the gut are functionally specialised to carry out specific roles in the niche they occupy, leading to an unprecedented understanding of the heterogeneity and potential biological functions of these cells. This review aims to integrate these novel findings with long-standing knowledge, to provide an updated overview on our understanding of macrophage function in the gastrointestinal tract and to speculate on the role of specialised subsets in the context of homoeostasis and disease.
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spelling pubmed-82236472021-07-09 Niche-specific functional heterogeneity of intestinal resident macrophages Viola, Maria Francesca Boeckxstaens, Guy Gut Recent Advances in Basic Science Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the response to food antigens and bacteria that are able to penetrate the mucosal barrier. However, recent advances in single-cell RNA sequencing technology have revealed that resident macrophages throughout the gut are functionally specialised to carry out specific roles in the niche they occupy, leading to an unprecedented understanding of the heterogeneity and potential biological functions of these cells. This review aims to integrate these novel findings with long-standing knowledge, to provide an updated overview on our understanding of macrophage function in the gastrointestinal tract and to speculate on the role of specialised subsets in the context of homoeostasis and disease. BMJ Publishing Group 2021-07 2020-12-31 /pmc/articles/PMC8223647/ /pubmed/33384336 http://dx.doi.org/10.1136/gutjnl-2020-323121 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Recent Advances in Basic Science
Viola, Maria Francesca
Boeckxstaens, Guy
Niche-specific functional heterogeneity of intestinal resident macrophages
title Niche-specific functional heterogeneity of intestinal resident macrophages
title_full Niche-specific functional heterogeneity of intestinal resident macrophages
title_fullStr Niche-specific functional heterogeneity of intestinal resident macrophages
title_full_unstemmed Niche-specific functional heterogeneity of intestinal resident macrophages
title_short Niche-specific functional heterogeneity of intestinal resident macrophages
title_sort niche-specific functional heterogeneity of intestinal resident macrophages
topic Recent Advances in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223647/
https://www.ncbi.nlm.nih.gov/pubmed/33384336
http://dx.doi.org/10.1136/gutjnl-2020-323121
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