Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil

A 55‐year‐old man was diagnosed with therapy‐related chronic myelomonocytic leukemia (t‐CMML) after exposure to tegafur/gimeracil/oteracil. Although he was refractory to hydroxyurea and low‐dose cytarabine, combination therapy with cytarabine, aclarubicin and azacitidine (CA‐AZA) provided good disea...

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Autores principales: Nakako, Soichiro, Takakuwa, Teruhito, Ichimura, Hirona, Okamura, Hiroshi, Nanno, Satoru, Nishimoto, Mitsutaka, Nakashima, Yasuhiro, Koh, Hideo, Hino, Masayuki, Nakamae, Hirohisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223688/
https://www.ncbi.nlm.nih.gov/pubmed/34194799
http://dx.doi.org/10.1002/ccr3.4298
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author Nakako, Soichiro
Takakuwa, Teruhito
Ichimura, Hirona
Okamura, Hiroshi
Nanno, Satoru
Nishimoto, Mitsutaka
Nakashima, Yasuhiro
Koh, Hideo
Hino, Masayuki
Nakamae, Hirohisa
author_facet Nakako, Soichiro
Takakuwa, Teruhito
Ichimura, Hirona
Okamura, Hiroshi
Nanno, Satoru
Nishimoto, Mitsutaka
Nakashima, Yasuhiro
Koh, Hideo
Hino, Masayuki
Nakamae, Hirohisa
author_sort Nakako, Soichiro
collection PubMed
description A 55‐year‐old man was diagnosed with therapy‐related chronic myelomonocytic leukemia (t‐CMML) after exposure to tegafur/gimeracil/oteracil. Although he was refractory to hydroxyurea and low‐dose cytarabine, combination therapy with cytarabine, aclarubicin and azacitidine (CA‐AZA) provided good disease control, and he underwent allogeneic stem cell transplantation. This report has two key massages. First, tegafur/gimeracil/oteracil may have a potential risk of developing t‐CMML. Second, CA‐AZA therapy may be considered as a therapeutic option for patients with t‐CMML.
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spelling pubmed-82236882021-06-29 Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil Nakako, Soichiro Takakuwa, Teruhito Ichimura, Hirona Okamura, Hiroshi Nanno, Satoru Nishimoto, Mitsutaka Nakashima, Yasuhiro Koh, Hideo Hino, Masayuki Nakamae, Hirohisa Clin Case Rep Case Reports A 55‐year‐old man was diagnosed with therapy‐related chronic myelomonocytic leukemia (t‐CMML) after exposure to tegafur/gimeracil/oteracil. Although he was refractory to hydroxyurea and low‐dose cytarabine, combination therapy with cytarabine, aclarubicin and azacitidine (CA‐AZA) provided good disease control, and he underwent allogeneic stem cell transplantation. This report has two key massages. First, tegafur/gimeracil/oteracil may have a potential risk of developing t‐CMML. Second, CA‐AZA therapy may be considered as a therapeutic option for patients with t‐CMML. John Wiley and Sons Inc. 2021-06-24 /pmc/articles/PMC8223688/ /pubmed/34194799 http://dx.doi.org/10.1002/ccr3.4298 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Nakako, Soichiro
Takakuwa, Teruhito
Ichimura, Hirona
Okamura, Hiroshi
Nanno, Satoru
Nishimoto, Mitsutaka
Nakashima, Yasuhiro
Koh, Hideo
Hino, Masayuki
Nakamae, Hirohisa
Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
title Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
title_full Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
title_fullStr Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
title_full_unstemmed Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
title_short Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
title_sort successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223688/
https://www.ncbi.nlm.nih.gov/pubmed/34194799
http://dx.doi.org/10.1002/ccr3.4298
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