Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation of Non-Canonical Branched-Chain Amino Acids by Combination of Pyruvate Pulses and Dissolved Oxygen Limitation

Insufficient mixing in large-scale bioreactors provokes gradient zones of substrate, dissolved oxygen (DO), pH, and other parameters. E. coli responds to a high glucose, low oxygen feeding zone with the accumulation of mixed acid fermentation products, especially formate, but also with the synthesis...

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Detalles Bibliográficos
Autores principales: García, Ángel Córcoles, Hauptmann, Peter, Neubauer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223794/
https://www.ncbi.nlm.nih.gov/pubmed/34063744
http://dx.doi.org/10.3390/microorganisms9061110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223794/
https://www.ncbi.nlm.nih.gov/pubmed/34063744
http://dx.doi.org/10.3390/microorganisms9061110

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