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Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism
The endocannabinoid system is involved in a wide range of processes including the control of energy acquisition and expenditure. Endocannabinoids and their receptors are present in the central nervous system but also in peripheral tissues, notably the adipose tissues. The endocannabinoid system inte...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224009/ https://www.ncbi.nlm.nih.gov/pubmed/34064024 http://dx.doi.org/10.3390/cells10061279 |
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author | Rakotoarivelo, Volatiana Sihag, Jyoti Flamand, Nicolas |
author_facet | Rakotoarivelo, Volatiana Sihag, Jyoti Flamand, Nicolas |
author_sort | Rakotoarivelo, Volatiana |
collection | PubMed |
description | The endocannabinoid system is involved in a wide range of processes including the control of energy acquisition and expenditure. Endocannabinoids and their receptors are present in the central nervous system but also in peripheral tissues, notably the adipose tissues. The endocannabinoid system interacts with two main hormones regulating appetite, namely leptin and ghrelin. The inhibitory effect of the cannabinoid receptor 1 (CB(1)) antagonist rimonabant on fat mass suggested that the endocannabinoid system can also have a peripheral action in addition to its effect on appetite reduction. Thus, several investigations have focused on the peripheral role of the endocannabinoid system in the regulation of metabolism. The white adipose tissue stores energy as triglycerides while the brown adipose tissue helps to dissipate energy as heat. The endocannabinoid system regulates several functions of the adipose tissues to favor energy accumulation. In this review we will describe the presence of the endocannabinoid system in the adipose tissue. We will survey the role of the endocannabinoid system in the regulation of white and brown adipose tissue metabolism and how the eCB system participates in obesity and metabolic diseases. |
format | Online Article Text |
id | pubmed-8224009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82240092021-06-25 Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism Rakotoarivelo, Volatiana Sihag, Jyoti Flamand, Nicolas Cells Review The endocannabinoid system is involved in a wide range of processes including the control of energy acquisition and expenditure. Endocannabinoids and their receptors are present in the central nervous system but also in peripheral tissues, notably the adipose tissues. The endocannabinoid system interacts with two main hormones regulating appetite, namely leptin and ghrelin. The inhibitory effect of the cannabinoid receptor 1 (CB(1)) antagonist rimonabant on fat mass suggested that the endocannabinoid system can also have a peripheral action in addition to its effect on appetite reduction. Thus, several investigations have focused on the peripheral role of the endocannabinoid system in the regulation of metabolism. The white adipose tissue stores energy as triglycerides while the brown adipose tissue helps to dissipate energy as heat. The endocannabinoid system regulates several functions of the adipose tissues to favor energy accumulation. In this review we will describe the presence of the endocannabinoid system in the adipose tissue. We will survey the role of the endocannabinoid system in the regulation of white and brown adipose tissue metabolism and how the eCB system participates in obesity and metabolic diseases. MDPI 2021-05-21 /pmc/articles/PMC8224009/ /pubmed/34064024 http://dx.doi.org/10.3390/cells10061279 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rakotoarivelo, Volatiana Sihag, Jyoti Flamand, Nicolas Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism |
title | Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism |
title_full | Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism |
title_fullStr | Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism |
title_full_unstemmed | Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism |
title_short | Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism |
title_sort | role of the endocannabinoid system in the adipose tissue with focus on energy metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224009/ https://www.ncbi.nlm.nih.gov/pubmed/34064024 http://dx.doi.org/10.3390/cells10061279 |
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