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Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection

From the beginning of SARS-CoV-2 virus pandemic, it was clear that respiratory symptoms are often accompanied with neurological symptoms. Neurological manifestations can occur even after mild forms of respiratory disease, and neurological symptoms are very often associated with worsening of the pati...

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Autores principales: Marcic, Ljiljana, Marcic, Marino, Kojundzic, Sanja Lovric, Marcic, Barbara, Capkun, Vesna, Vukojevic, Katarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224015/
https://www.ncbi.nlm.nih.gov/pubmed/34063824
http://dx.doi.org/10.3390/jpm11060442
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author Marcic, Ljiljana
Marcic, Marino
Kojundzic, Sanja Lovric
Marcic, Barbara
Capkun, Vesna
Vukojevic, Katarina
author_facet Marcic, Ljiljana
Marcic, Marino
Kojundzic, Sanja Lovric
Marcic, Barbara
Capkun, Vesna
Vukojevic, Katarina
author_sort Marcic, Ljiljana
collection PubMed
description From the beginning of SARS-CoV-2 virus pandemic, it was clear that respiratory symptoms are often accompanied with neurological symptoms. Neurological manifestations can occur even after mild forms of respiratory disease, and neurological symptoms are very often associated with worsening of the patient’s condition. The aim of this study was to show abnormal brain neuroimaging findings evaluated by MRI in patients after SARS-CoV-2 infection and neurological symptoms. Methods: Sixteen patients after mild forms of SARS-CoV-2 infection, twenty-three patients after moderate forms of SARS-CoV-2 infection as well as sixteen healthy participants in the control group underwent MRI 3T brain scan. All subjects in the SARS-CoV-2 group had small, punctuate, strategically located and newly formed hyperintense lesions on T2 and FLAIR sequences. New lesions were formed more often in the bilateral frontal subcortical and bilateral periventricular, correlated with the severity of the clinical picture. These changes indicate an example of silent cerebrovascular disease related to SARS-CoV-2 and once again emphasize the neurotropism of the virus.
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spelling pubmed-82240152021-06-25 Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection Marcic, Ljiljana Marcic, Marino Kojundzic, Sanja Lovric Marcic, Barbara Capkun, Vesna Vukojevic, Katarina J Pers Med Article From the beginning of SARS-CoV-2 virus pandemic, it was clear that respiratory symptoms are often accompanied with neurological symptoms. Neurological manifestations can occur even after mild forms of respiratory disease, and neurological symptoms are very often associated with worsening of the patient’s condition. The aim of this study was to show abnormal brain neuroimaging findings evaluated by MRI in patients after SARS-CoV-2 infection and neurological symptoms. Methods: Sixteen patients after mild forms of SARS-CoV-2 infection, twenty-three patients after moderate forms of SARS-CoV-2 infection as well as sixteen healthy participants in the control group underwent MRI 3T brain scan. All subjects in the SARS-CoV-2 group had small, punctuate, strategically located and newly formed hyperintense lesions on T2 and FLAIR sequences. New lesions were formed more often in the bilateral frontal subcortical and bilateral periventricular, correlated with the severity of the clinical picture. These changes indicate an example of silent cerebrovascular disease related to SARS-CoV-2 and once again emphasize the neurotropism of the virus. MDPI 2021-05-21 /pmc/articles/PMC8224015/ /pubmed/34063824 http://dx.doi.org/10.3390/jpm11060442 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marcic, Ljiljana
Marcic, Marino
Kojundzic, Sanja Lovric
Marcic, Barbara
Capkun, Vesna
Vukojevic, Katarina
Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection
title Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection
title_full Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection
title_fullStr Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection
title_full_unstemmed Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection
title_short Personalized Approach to Patient with MRI Brain Changes after SARS-CoV-2 Infection
title_sort personalized approach to patient with mri brain changes after sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224015/
https://www.ncbi.nlm.nih.gov/pubmed/34063824
http://dx.doi.org/10.3390/jpm11060442
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