Cargando…

The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing

Skin barrier damage can be the result of various external factors including heat, radiation, chemicals and many others. Any interruption of the skin barrier integrity causes the exposure of the organism to harmful environmental factors. Therefore, there is an urgent need to develop novel therapeutic...

Descripción completa

Detalles Bibliográficos
Autores principales: Malinowska, Magdalena Anna, Sikora, Elżbieta, Stalińska, Joanna, Ogonowski, Jan, Drukała, Justyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224297/
https://www.ncbi.nlm.nih.gov/pubmed/34064164
http://dx.doi.org/10.3390/biom11060774
_version_ 1783711857924636672
author Malinowska, Magdalena Anna
Sikora, Elżbieta
Stalińska, Joanna
Ogonowski, Jan
Drukała, Justyna
author_facet Malinowska, Magdalena Anna
Sikora, Elżbieta
Stalińska, Joanna
Ogonowski, Jan
Drukała, Justyna
author_sort Malinowska, Magdalena Anna
collection PubMed
description Skin barrier damage can be the result of various external factors including heat, radiation, chemicals and many others. Any interruption of the skin barrier integrity causes the exposure of the organism to harmful environmental factors. Therefore, there is an urgent need to develop novel therapeutics characterized by high bioavailability and effectiveness in skin damage recovery. Birch bark is known as a clinically proven, traditional medicinal remedy to accelerate wound healing. Lupeol, one of the main birch bark ingredients, shows a wide range of biological activity beneficial to the skin. The purpose of the research was to determine the influence of new lupeol derivatives on keratinocyte and fibroblast migration and proliferation, as well as to investigate various mechanisms of their antioxidant activity. The chemical modification of lupeol structure was intended to obtain more effective therapeutics characterized by higher bioavailability, permeability and safety of use. The novel triterpenes presented in this study were evaluated as the potential active ingredients preventing skin tissue degradation. Lupeol esters influence skin cells’ motility and proliferation. Importantly, they are able to reduce reactive oxygen species and act indirectly by protecting the skin protein structure from being oxidized by free radicals.
format Online
Article
Text
id pubmed-8224297
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82242972021-06-25 The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing Malinowska, Magdalena Anna Sikora, Elżbieta Stalińska, Joanna Ogonowski, Jan Drukała, Justyna Biomolecules Article Skin barrier damage can be the result of various external factors including heat, radiation, chemicals and many others. Any interruption of the skin barrier integrity causes the exposure of the organism to harmful environmental factors. Therefore, there is an urgent need to develop novel therapeutics characterized by high bioavailability and effectiveness in skin damage recovery. Birch bark is known as a clinically proven, traditional medicinal remedy to accelerate wound healing. Lupeol, one of the main birch bark ingredients, shows a wide range of biological activity beneficial to the skin. The purpose of the research was to determine the influence of new lupeol derivatives on keratinocyte and fibroblast migration and proliferation, as well as to investigate various mechanisms of their antioxidant activity. The chemical modification of lupeol structure was intended to obtain more effective therapeutics characterized by higher bioavailability, permeability and safety of use. The novel triterpenes presented in this study were evaluated as the potential active ingredients preventing skin tissue degradation. Lupeol esters influence skin cells’ motility and proliferation. Importantly, they are able to reduce reactive oxygen species and act indirectly by protecting the skin protein structure from being oxidized by free radicals. MDPI 2021-05-21 /pmc/articles/PMC8224297/ /pubmed/34064164 http://dx.doi.org/10.3390/biom11060774 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Malinowska, Magdalena Anna
Sikora, Elżbieta
Stalińska, Joanna
Ogonowski, Jan
Drukała, Justyna
The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing
title The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing
title_full The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing
title_fullStr The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing
title_full_unstemmed The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing
title_short The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing
title_sort effect of the new lupeol derivatives on human skin cells as potential agents in the treatment of wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224297/
https://www.ncbi.nlm.nih.gov/pubmed/34064164
http://dx.doi.org/10.3390/biom11060774
work_keys_str_mv AT malinowskamagdalenaanna theeffectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT sikoraelzbieta theeffectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT stalinskajoanna theeffectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT ogonowskijan theeffectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT drukałajustyna theeffectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT malinowskamagdalenaanna effectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT sikoraelzbieta effectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT stalinskajoanna effectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT ogonowskijan effectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing
AT drukałajustyna effectofthenewlupeolderivativesonhumanskincellsaspotentialagentsinthetreatmentofwoundhealing