Cargando…

What Is Abnormal in Normal Karyotype Acute Myeloid Leukemia in Children? Analysis of the Mutational Landscape and Prognosis of the TARGET-AML Cohort

Normal karyotype acute myeloid leukemia (NK-AML) constitutes 20–25% of pediatric AML and detailed molecular analysis is essential to unravel the genetic background of this group. Using publicly available sequencing data from the TARGET-AML initiative, we investigated the mutational landscape of NK-A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herlin, Morten Krogh, Yones, Sara A., Kjeldsen, Eigil, Holmfeldt, Linda, Hasle, Henrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224370/ https://www.ncbi.nlm.nih.gov/pubmed/34064268 http://dx.doi.org/10.3390/genes12060792

Ejemplares similares

Karyotype complexity and prognosis in acute myeloid leukemia
por: Stölzel, F, et al.
Publicado: (2016)

Analysis of SNP Array Abnormalities in Patients with DE NOVO Acute Myeloid Leukemia with Normal Karyotype
por: Ibáñez, Mariam, et al.
Publicado: (2020)

Extreme hyperleukocytosis in a pediatric T-ALL patient with a rare translocation, t(7;19)(q35;p13), and submicroscopic deletions at 4q25, 7q33 and 10q23()
por: Veigaard, Christopher, et al.
Publicado: (2013)

Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
por: Stratmann, Svea, et al.
Publicado: (2022)

Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotypes
por: Xu, Junqing, et al.
Publicado: (2017)

New Fusion Transcripts Identified in Normal Karyotype Acute Myeloid Leukemia
por: Wen, Hongxiu, et al.
Publicado: (2012)

Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
por: Petti, Allegra A., et al.
Publicado: (2022)

ELMO1 Is Upregulated in AML CD34+ Stem/Progenitor Cells, Mediates Chemotaxis and Predicts Poor Prognosis in Normal Karyotype AML
por: Capala, Marta E., et al.
Publicado: (2014)

Characteristics and outcomes of patients with therapy-related acute myeloid leukemia with normal karyotype
por: Samra, Bachar, et al.
Publicado: (2020)

DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
por: Krali, Olga, et al.
Publicado: (2021)

A novel insertion ins(18;5)(q21.1;q31.2q35.1) in acute myeloid leukemia associated with microdeletions at 5q31.2, 5q35.1q35.2 and 18q12.3q21.1 detected by oligobased array comparative genomic hybridization
por: Kjeldsen, Eigil
Publicado: (2014)

Arthritis as presenting manifestation of acute lymphoblastic leukemia in children
por: Brix, Ninna, et al.
Publicado: (2014)

Novel Mutations in CEBPA in Korean Patients with Acute Myeloid Leukemia with a Normal Karyotype
por: Kim, Sollip, et al.
Publicado: (2012)

Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes
por: Ferraro, Francesca, et al.
Publicado: (2021)

Investigation of Biomarkers Associated with Low Platelet Counts in Normal Karyotype Acute Myeloid Leukemia
por: Park, Chang-Hun, et al.
Publicado: (2022)

A de novo acute myeloid leukemia (AML-M4) case with a complex karyotype and yet unreported breakpoints
por: Al-achkar, Walid, et al.
Publicado: (2013)

Duplication of subtelomeric regions in an adult with acute monocytic leukemia with an acquired jumping translocation involving 3q13.31-qter
por: Kjeldsen, Eigil
Publicado: (2017)

Congenital Aneuploidy in Klinefelter Syndrome with B-Cell Acute Lymphoblastic Leukemia Might Be Associated with Chromosomal Instability and Reduced Telomere Length
por: Kjeldsen, Eigil
Publicado: (2022)

Genetic Risk Prediction for Normal-Karyotype Acute Myeloid Leukemia Using Whole-Exome Sequencing
por: Heo, Seong Gu, et al.
Publicado: (2013)

Assessment of a new genomic classification system in acute myeloid leukemia with a normal karyotype
por: Ahn, Jae-Sook, et al.
Publicado: (2017)

Immunotherapy with HDC/IL-2 may be clinically efficacious in acute myeloid leukemia of normal karyotype
por: Nilsson, Malin S., et al.
Publicado: (2019)

Clinical Significance of bZIP In-Frame CEBPA-Mutated Normal Karyotype Acute Myeloid Leukemia
por: Ahn, Seo-Yeon, et al.
Publicado: (2023)

Data on affected cancer-related genes in pediatric t(12;21)-positive acute lymphoblastic leukemia patients harboring unbalanced der(6)t(X;6) translocations
por: Kjeldsen, Eigil
Publicado: (2016)

KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia
por: Lopes, Marta, et al.
Publicado: (2018)

Identifying acute lymphoblastic leukemia mimicking juvenile idiopathic arthritis in children
por: Brix, Ninna, et al.
Publicado: (2020)

Chromosomal rearrangements in acute myeloid leukemia (AML)
por: Belloni, E, et al.
Publicado: (2010)

New agents in acute myeloid leukemia (AML)
por: Park, Silvia, et al.
Publicado: (2020)

AngioCRIME in Acute Myeloid Leukemia (AML)
por: Macintyre, Elizabeth
Publicado: (2017)

The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients
por: Pravdic, Zlatko, et al.
Publicado: (2023)

Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse
por: Park, Sang Hyuk, et al.
Publicado: (2011)

An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype
por: Chuang, Ming-Kai, et al.
Publicado: (2015)

Downregulation of SMIM3 inhibits growth of leukemia via PI3K-AKT signaling pathway and correlates with prognosis of adult acute myeloid leukemia with normal karyotype
por: Liu, Yu, et al.
Publicado: (2022)

Mutation Patterns of 16 Genes in Primary and Secondary Acute Myeloid Leukemia (AML) with Normal Cytogenetics
por: Fernandez-Mercado, Marta, et al.
Publicado: (2012)

Karyotypic findings in chronic myeloid leukemia cases undergoing treatment
por: Kaur, Anupam, et al.
Publicado: (2012)

Is karyotyping still needed in the diagnosis and monitoring of chronic myeloid leukemia?
por: Chauffaille, Maria de Lourdes L.F.
Publicado: (2017)

P440: ENHANCER HIJACKING IN COMPLEX-KARYOTYPE AML
por: Sollier, Etienne, et al.
Publicado: (2023)

Downregulation of GNA15 Inhibits Cell Proliferation via P38 MAPK Pathway and Correlates with Prognosis of Adult Acute Myeloid Leukemia With Normal Karyotype
por: Li, Mengya, et al.
Publicado: (2021)

Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children
por: Stratmann, Svea, et al.
Publicado: (2022)

Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients
por: Park, Sang Hyuk, et al.
Publicado: (2015)

ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia‐related changes and normal karyotype
por: Prats‐Martín, Concepción, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ctmb032ki7g1f0oc3mh6ihe6af