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Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency
In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancem...
Autores principales: | Violaris, Ioannis G., Kalafatakis, Konstantinos, Zavala, Eder, Tsoulos, Ioannis G., Lampros, Theodoros, Lightman, Stafford L., Tsipouras, Markos G., Giannakeas, Nikolaos, Tzallas, Alexandros, Russell, Georgina M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224376/ https://www.ncbi.nlm.nih.gov/pubmed/34064165 http://dx.doi.org/10.3390/pharmaceutics13060769 |
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