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Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery
The different pathways between the position of a near-infrared camera and the user’s eye limit the use of existing near-infrared fluorescence imaging systems for tumor margin assessments. By utilizing an optical system that precisely matches the near-infrared fluorescence image and the optical path...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224390/ https://www.ncbi.nlm.nih.gov/pubmed/34064205 http://dx.doi.org/10.3390/diagnostics11060927 |
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author | Lee, Seung Hyun Quan, Yu Hua Kim, Min Sub Kwon, Ki Hyeok Choi, Byeong Hyeon Kim, Hyun Koo Kim, Beop-Min |
author_facet | Lee, Seung Hyun Quan, Yu Hua Kim, Min Sub Kwon, Ki Hyeok Choi, Byeong Hyeon Kim, Hyun Koo Kim, Beop-Min |
author_sort | Lee, Seung Hyun |
collection | PubMed |
description | The different pathways between the position of a near-infrared camera and the user’s eye limit the use of existing near-infrared fluorescence imaging systems for tumor margin assessments. By utilizing an optical system that precisely matches the near-infrared fluorescence image and the optical path of visible light, we developed an augmented reality (AR)-based fluorescence imaging system that provides users with a fluorescence image that matches the real-field, without requiring any additional algorithms. Commercial smart glasses, dichroic beam splitters, mirrors, and custom near-infrared cameras were employed to develop the proposed system, and each mount was designed and utilized. After its performance was assessed in the laboratory, preclinical experiments involving tumor detection and lung lobectomy in mice and rabbits by using indocyanine green (ICG) were conducted. The results showed that the proposed system provided a stable image of fluorescence that matched the actual site. In addition, preclinical experiments confirmed that the proposed system could be used to detect tumors using ICG and evaluate lung lobectomies. The AR-based intraoperative smart goggle system could detect fluorescence images for tumor margin assessments in animal models, without disrupting the surgical workflow in an operating room. Additionally, it was confirmed that, even when the system itself was distorted when worn, the fluorescence image consistently matched the actual site. |
format | Online Article Text |
id | pubmed-8224390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82243902021-06-25 Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery Lee, Seung Hyun Quan, Yu Hua Kim, Min Sub Kwon, Ki Hyeok Choi, Byeong Hyeon Kim, Hyun Koo Kim, Beop-Min Diagnostics (Basel) Article The different pathways between the position of a near-infrared camera and the user’s eye limit the use of existing near-infrared fluorescence imaging systems for tumor margin assessments. By utilizing an optical system that precisely matches the near-infrared fluorescence image and the optical path of visible light, we developed an augmented reality (AR)-based fluorescence imaging system that provides users with a fluorescence image that matches the real-field, without requiring any additional algorithms. Commercial smart glasses, dichroic beam splitters, mirrors, and custom near-infrared cameras were employed to develop the proposed system, and each mount was designed and utilized. After its performance was assessed in the laboratory, preclinical experiments involving tumor detection and lung lobectomy in mice and rabbits by using indocyanine green (ICG) were conducted. The results showed that the proposed system provided a stable image of fluorescence that matched the actual site. In addition, preclinical experiments confirmed that the proposed system could be used to detect tumors using ICG and evaluate lung lobectomies. The AR-based intraoperative smart goggle system could detect fluorescence images for tumor margin assessments in animal models, without disrupting the surgical workflow in an operating room. Additionally, it was confirmed that, even when the system itself was distorted when worn, the fluorescence image consistently matched the actual site. MDPI 2021-05-21 /pmc/articles/PMC8224390/ /pubmed/34064205 http://dx.doi.org/10.3390/diagnostics11060927 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Seung Hyun Quan, Yu Hua Kim, Min Sub Kwon, Ki Hyeok Choi, Byeong Hyeon Kim, Hyun Koo Kim, Beop-Min Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery |
title | Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery |
title_full | Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery |
title_fullStr | Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery |
title_full_unstemmed | Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery |
title_short | Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery |
title_sort | design and testing of augmented reality-based fluorescence imaging goggle for intraoperative imaging-guided surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224390/ https://www.ncbi.nlm.nih.gov/pubmed/34064205 http://dx.doi.org/10.3390/diagnostics11060927 |
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