HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence

Spatial organization and gene expression of mammalian chromosomes are maintained and regulated in conjunction with cell cycle progression. This is perturbed once cells enter senescence and the highly abundant HMGB1 protein is depleted from nuclei to act as an extracellular proinflammatory stimulus....

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Detalles Bibliográficos
Autores principales: Sofiadis, Konstantinos, Josipovic, Natasa, Nikolic, Milos, Kargapolova, Yulia, Übelmesser, Nadine, Varamogianni‐Mamatsi, Vassiliki, Zirkel, Anne, Papadionysiou, Ioanna, Loughran, Gary, Keane, James, Michel, Audrey, Gusmao, Eduardo G, Becker, Christian, Altmüller, Janine, Georgomanolis, Theodore, Mizi, Athanasia, Papantonis, Argyris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224457/
https://www.ncbi.nlm.nih.gov/pubmed/34166567
http://dx.doi.org/10.15252/msb.20209760

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