Cargando…

Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes

Background: It is not yet clear whether nutritional status is associated with post-stroke cognitive impairment (PSCI). We examined the geriatric nutritional risk index (GNRI) on the domain-specific cognitive outcomes 3 months after a stroke. Methods: A total of 344 patients with acute ischemic strok...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Minwoo, Lim, Jae-Sung, Kim, Yerim, Lee, Ju Hun, Kim, Chul-Ho, Lee, Sang-Hwa, Jang, Min Uk, Oh, Mi Sun, Lee, Byung-Chul, Yu, Kyung-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224551/
https://www.ncbi.nlm.nih.gov/pubmed/34070955
http://dx.doi.org/10.3390/nu13061776
_version_ 1783711909296472064
author Lee, Minwoo
Lim, Jae-Sung
Kim, Yerim
Lee, Ju Hun
Kim, Chul-Ho
Lee, Sang-Hwa
Jang, Min Uk
Oh, Mi Sun
Lee, Byung-Chul
Yu, Kyung-Ho
author_facet Lee, Minwoo
Lim, Jae-Sung
Kim, Yerim
Lee, Ju Hun
Kim, Chul-Ho
Lee, Sang-Hwa
Jang, Min Uk
Oh, Mi Sun
Lee, Byung-Chul
Yu, Kyung-Ho
author_sort Lee, Minwoo
collection PubMed
description Background: It is not yet clear whether nutritional status is associated with post-stroke cognitive impairment (PSCI). We examined the geriatric nutritional risk index (GNRI) on the domain-specific cognitive outcomes 3 months after a stroke. Methods: A total of 344 patients with acute ischemic stroke were included for the analysis. The GNRI was calculated as 1.489 × serum albumin (g/L) + 41.7 × admission weight (kg)/ideal body weight (kg) and was dichotomized according to the prespecified cut-off points for no risk and any risks. The primary outcome was PSCI, defined as having adjusted z-scores of less than −2 standard deviations in at least one cognitive domain: executive/activation, memory, visuospatial and language. Multiple logistic regression and linear regression analyses were performed to investigate the association between the GNRI and cognitive outcomes. Results: Seventy (20.3%) patients developed PSCI 3 months after a stroke. The mean GNRI was 106.1 ± 8.6, and 59 (17.2%) patients had low (<98) GNRI scores. A low GNRI was independently associated with the PSCI after adjusting for age, sex, education, initial stroke severity, stroke mechanism and left hemispheric lesion (odds ratio, 2.04; 95% confidence interval, 1.00–4.14). The GNRI scores were also significantly associated with the z-scores from the mini-mental status examination and the frontal domain (β = 0.04, p-value = 0.03; β = 0.03, p-value = 0.03, respectively). Conclusions: A low GNRI was independently associated with the development of PSCI at 3 months after an ischemic stroke. The GNRI scores were specifically associated with the z-scores of the global cognition and frontal domain cognitive outcomes.
format Online
Article
Text
id pubmed-8224551
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82245512021-06-25 Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes Lee, Minwoo Lim, Jae-Sung Kim, Yerim Lee, Ju Hun Kim, Chul-Ho Lee, Sang-Hwa Jang, Min Uk Oh, Mi Sun Lee, Byung-Chul Yu, Kyung-Ho Nutrients Article Background: It is not yet clear whether nutritional status is associated with post-stroke cognitive impairment (PSCI). We examined the geriatric nutritional risk index (GNRI) on the domain-specific cognitive outcomes 3 months after a stroke. Methods: A total of 344 patients with acute ischemic stroke were included for the analysis. The GNRI was calculated as 1.489 × serum albumin (g/L) + 41.7 × admission weight (kg)/ideal body weight (kg) and was dichotomized according to the prespecified cut-off points for no risk and any risks. The primary outcome was PSCI, defined as having adjusted z-scores of less than −2 standard deviations in at least one cognitive domain: executive/activation, memory, visuospatial and language. Multiple logistic regression and linear regression analyses were performed to investigate the association between the GNRI and cognitive outcomes. Results: Seventy (20.3%) patients developed PSCI 3 months after a stroke. The mean GNRI was 106.1 ± 8.6, and 59 (17.2%) patients had low (<98) GNRI scores. A low GNRI was independently associated with the PSCI after adjusting for age, sex, education, initial stroke severity, stroke mechanism and left hemispheric lesion (odds ratio, 2.04; 95% confidence interval, 1.00–4.14). The GNRI scores were also significantly associated with the z-scores from the mini-mental status examination and the frontal domain (β = 0.04, p-value = 0.03; β = 0.03, p-value = 0.03, respectively). Conclusions: A low GNRI was independently associated with the development of PSCI at 3 months after an ischemic stroke. The GNRI scores were specifically associated with the z-scores of the global cognition and frontal domain cognitive outcomes. MDPI 2021-05-23 /pmc/articles/PMC8224551/ /pubmed/34070955 http://dx.doi.org/10.3390/nu13061776 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Minwoo
Lim, Jae-Sung
Kim, Yerim
Lee, Ju Hun
Kim, Chul-Ho
Lee, Sang-Hwa
Jang, Min Uk
Oh, Mi Sun
Lee, Byung-Chul
Yu, Kyung-Ho
Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
title Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
title_full Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
title_fullStr Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
title_full_unstemmed Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
title_short Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
title_sort association between geriatric nutritional risk index and post-stroke cognitive outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224551/
https://www.ncbi.nlm.nih.gov/pubmed/34070955
http://dx.doi.org/10.3390/nu13061776
work_keys_str_mv AT leeminwoo associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT limjaesung associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT kimyerim associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT leejuhun associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT kimchulho associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT leesanghwa associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT jangminuk associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT ohmisun associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT leebyungchul associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes
AT yukyungho associationbetweengeriatricnutritionalriskindexandpoststrokecognitiveoutcomes