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Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France

Vaccination programs against COVID-19 are being scaled up. We aimed to assess the effects of vaccine characteristics on vaccine hesitancy among healthcare workers in a multi-center survey conducted within French healthcare facilities from 1 December 2020 to 26 March 2021. We invited any healthcare w...

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Autores principales: Janssen, Cécile, Maillard, Alexis, Bodelet, Céline, Claudel, Anne-Laure, Gaillat, Jacques, Delory, Tristan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224571/
https://www.ncbi.nlm.nih.gov/pubmed/34067490
http://dx.doi.org/10.3390/vaccines9060547
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author Janssen, Cécile
Maillard, Alexis
Bodelet, Céline
Claudel, Anne-Laure
Gaillat, Jacques
Delory, Tristan
author_facet Janssen, Cécile
Maillard, Alexis
Bodelet, Céline
Claudel, Anne-Laure
Gaillat, Jacques
Delory, Tristan
author_sort Janssen, Cécile
collection PubMed
description Vaccination programs against COVID-19 are being scaled up. We aimed to assess the effects of vaccine characteristics on vaccine hesitancy among healthcare workers in a multi-center survey conducted within French healthcare facilities from 1 December 2020 to 26 March 2021. We invited any healthcare workers naïve of COVID-19 vaccination to complete an online self-questionnaire. They reported on their socio-demographic characteristics, as well as their perception and beliefs towards vaccination. We measured their willingness to get vaccinated in eight scenarios for candidates’ vaccines presented sequentially (1 to 4-point scale). Candidates’ vaccines varied for efficacy (25%, 50%, 100%), length of immunization (1 year or lifetime), frequency (<1/100, <1/10,000), and severity (none, moderate, severe) of adverse events. We analyzed 4349 healthcare workers’ responses with interpretable questionnaires. The crude willingness to get vaccinated was 53.2% and increased over time. We clustered the trajectories of responses using an unsupervised classification algorithm (k-means) and identified four groups of healthcare workers: those willing to get vaccinated in any scenario (18%), those not willing to get vaccinated at all (22%), and those hesitating but more likely to accept (32%) or reject (28%) the vaccination depending on the scenario. In these last two subgroups, vaccine acceptance was growing with age, educational background and was higher among men with condition. Compared to an ideal vaccine candidate, a 50% reduced efficacy resulted in an average drop in acceptance by 0.8 (SD ± 0.8, −23.5%), while it was ranging from 1.4 (SD ± 1.0, −38.4%) to 2.1 (SD ± 1.0, −58.4%) in case of severe but rare adverse event. The acceptance of a mandatory immunization program was 29.6% overall and was positively correlated to the willingness to get vaccinated, ranging from 2.4% to 60.0%. Even if healthcare workers represent a heterogeneous population, most (80%) could accept the vaccination against COVID-19. Their willingness to get the vaccine increased over time and as immunization programs became available. Among hesitant professionals, the fear of adverse events was the main concern. Targeted information campaigns reassuring about adverse events may increase vaccine coverage, in a population with a strong opinion about mandatory immunization programs.
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spelling pubmed-82245712021-06-25 Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France Janssen, Cécile Maillard, Alexis Bodelet, Céline Claudel, Anne-Laure Gaillat, Jacques Delory, Tristan Vaccines (Basel) Article Vaccination programs against COVID-19 are being scaled up. We aimed to assess the effects of vaccine characteristics on vaccine hesitancy among healthcare workers in a multi-center survey conducted within French healthcare facilities from 1 December 2020 to 26 March 2021. We invited any healthcare workers naïve of COVID-19 vaccination to complete an online self-questionnaire. They reported on their socio-demographic characteristics, as well as their perception and beliefs towards vaccination. We measured their willingness to get vaccinated in eight scenarios for candidates’ vaccines presented sequentially (1 to 4-point scale). Candidates’ vaccines varied for efficacy (25%, 50%, 100%), length of immunization (1 year or lifetime), frequency (<1/100, <1/10,000), and severity (none, moderate, severe) of adverse events. We analyzed 4349 healthcare workers’ responses with interpretable questionnaires. The crude willingness to get vaccinated was 53.2% and increased over time. We clustered the trajectories of responses using an unsupervised classification algorithm (k-means) and identified four groups of healthcare workers: those willing to get vaccinated in any scenario (18%), those not willing to get vaccinated at all (22%), and those hesitating but more likely to accept (32%) or reject (28%) the vaccination depending on the scenario. In these last two subgroups, vaccine acceptance was growing with age, educational background and was higher among men with condition. Compared to an ideal vaccine candidate, a 50% reduced efficacy resulted in an average drop in acceptance by 0.8 (SD ± 0.8, −23.5%), while it was ranging from 1.4 (SD ± 1.0, −38.4%) to 2.1 (SD ± 1.0, −58.4%) in case of severe but rare adverse event. The acceptance of a mandatory immunization program was 29.6% overall and was positively correlated to the willingness to get vaccinated, ranging from 2.4% to 60.0%. Even if healthcare workers represent a heterogeneous population, most (80%) could accept the vaccination against COVID-19. Their willingness to get the vaccine increased over time and as immunization programs became available. Among hesitant professionals, the fear of adverse events was the main concern. Targeted information campaigns reassuring about adverse events may increase vaccine coverage, in a population with a strong opinion about mandatory immunization programs. MDPI 2021-05-22 /pmc/articles/PMC8224571/ /pubmed/34067490 http://dx.doi.org/10.3390/vaccines9060547 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Janssen, Cécile
Maillard, Alexis
Bodelet, Céline
Claudel, Anne-Laure
Gaillat, Jacques
Delory, Tristan
Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France
title Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France
title_full Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France
title_fullStr Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France
title_full_unstemmed Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France
title_short Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France
title_sort hesitancy towards covid-19 vaccination among healthcare workers: a multi-centric survey in france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224571/
https://www.ncbi.nlm.nih.gov/pubmed/34067490
http://dx.doi.org/10.3390/vaccines9060547
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