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Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224578/ https://www.ncbi.nlm.nih.gov/pubmed/34071118 http://dx.doi.org/10.3390/microorganisms9061129 |
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author | Hsin, Li-Jen Chuang, Hai-Hua Lin, Mu-Yun Fang, Tuan-Jen Li, Hsueh-Yu Liao, Chun-Ta Kang, Chung-Jan Chen, Tse-Ching Huang, Chung-Guei Yen, Tzu-Chen Lee, Li-Ang |
author_facet | Hsin, Li-Jen Chuang, Hai-Hua Lin, Mu-Yun Fang, Tuan-Jen Li, Hsueh-Yu Liao, Chun-Ta Kang, Chung-Jan Chen, Tse-Ching Huang, Chung-Guei Yen, Tzu-Chen Lee, Li-Ang |
author_sort | Hsin, Li-Jen |
collection | PubMed |
description | Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal H. pylori infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of H. pylori DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, H. pylori-associated laryngopharyngeal reflux and the expression of E-cadherin and CD1d (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal H. pylori infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal H. pylori infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan. |
format | Online Article Text |
id | pubmed-8224578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82245782021-06-25 Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review Hsin, Li-Jen Chuang, Hai-Hua Lin, Mu-Yun Fang, Tuan-Jen Li, Hsueh-Yu Liao, Chun-Ta Kang, Chung-Jan Chen, Tse-Ching Huang, Chung-Guei Yen, Tzu-Chen Lee, Li-Ang Microorganisms Article Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal H. pylori infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of H. pylori DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, H. pylori-associated laryngopharyngeal reflux and the expression of E-cadherin and CD1d (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal H. pylori infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal H. pylori infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan. MDPI 2021-05-23 /pmc/articles/PMC8224578/ /pubmed/34071118 http://dx.doi.org/10.3390/microorganisms9061129 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hsin, Li-Jen Chuang, Hai-Hua Lin, Mu-Yun Fang, Tuan-Jen Li, Hsueh-Yu Liao, Chun-Ta Kang, Chung-Jan Chen, Tse-Ching Huang, Chung-Guei Yen, Tzu-Chen Lee, Li-Ang Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title | Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_full | Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_fullStr | Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_full_unstemmed | Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_short | Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review |
title_sort | laryngeal helicobacter pylori infection and laryngeal cancer-case series and a systematic review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224578/ https://www.ncbi.nlm.nih.gov/pubmed/34071118 http://dx.doi.org/10.3390/microorganisms9061129 |
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