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Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review

Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible...

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Autores principales: Hsin, Li-Jen, Chuang, Hai-Hua, Lin, Mu-Yun, Fang, Tuan-Jen, Li, Hsueh-Yu, Liao, Chun-Ta, Kang, Chung-Jan, Chen, Tse-Ching, Huang, Chung-Guei, Yen, Tzu-Chen, Lee, Li-Ang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224578/
https://www.ncbi.nlm.nih.gov/pubmed/34071118
http://dx.doi.org/10.3390/microorganisms9061129
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author Hsin, Li-Jen
Chuang, Hai-Hua
Lin, Mu-Yun
Fang, Tuan-Jen
Li, Hsueh-Yu
Liao, Chun-Ta
Kang, Chung-Jan
Chen, Tse-Ching
Huang, Chung-Guei
Yen, Tzu-Chen
Lee, Li-Ang
author_facet Hsin, Li-Jen
Chuang, Hai-Hua
Lin, Mu-Yun
Fang, Tuan-Jen
Li, Hsueh-Yu
Liao, Chun-Ta
Kang, Chung-Jan
Chen, Tse-Ching
Huang, Chung-Guei
Yen, Tzu-Chen
Lee, Li-Ang
author_sort Hsin, Li-Jen
collection PubMed
description Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal H. pylori infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of H. pylori DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, H. pylori-associated laryngopharyngeal reflux and the expression of E-cadherin and CD1d (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal H. pylori infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal H. pylori infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan.
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spelling pubmed-82245782021-06-25 Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review Hsin, Li-Jen Chuang, Hai-Hua Lin, Mu-Yun Fang, Tuan-Jen Li, Hsueh-Yu Liao, Chun-Ta Kang, Chung-Jan Chen, Tse-Ching Huang, Chung-Guei Yen, Tzu-Chen Lee, Li-Ang Microorganisms Article Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal H. pylori infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of H. pylori DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, H. pylori-associated laryngopharyngeal reflux and the expression of E-cadherin and CD1d (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal H. pylori infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal H. pylori infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan. MDPI 2021-05-23 /pmc/articles/PMC8224578/ /pubmed/34071118 http://dx.doi.org/10.3390/microorganisms9061129 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsin, Li-Jen
Chuang, Hai-Hua
Lin, Mu-Yun
Fang, Tuan-Jen
Li, Hsueh-Yu
Liao, Chun-Ta
Kang, Chung-Jan
Chen, Tse-Ching
Huang, Chung-Guei
Yen, Tzu-Chen
Lee, Li-Ang
Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
title Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
title_full Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
title_fullStr Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
title_full_unstemmed Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
title_short Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
title_sort laryngeal helicobacter pylori infection and laryngeal cancer-case series and a systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224578/
https://www.ncbi.nlm.nih.gov/pubmed/34071118
http://dx.doi.org/10.3390/microorganisms9061129
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