Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction

Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One...

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Detalles Bibliográficos
Autores principales: Chung, Tom Wai-Hin, Zhang, Hui, Wong, Fergus Kai-Chuen, Sridhar, Siddharth, Chan, Kwok-Hung, Cheng, Vincent Chi-Chung, Yuen, Kwok-Yung, Hung, Ivan Fan-Ngai, Mak, Henry Ka-Fung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224593/
https://www.ncbi.nlm.nih.gov/pubmed/34071007
http://dx.doi.org/10.3390/brainsci11060686
Descripción
Sumario:Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm(3) to 49.5 mm(3) (120%), left: 37.5 mm(3) to 42 mm(3) (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].

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