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Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool

Motive. The Covid-19 pandemic has led to the novel situation that hospitals must prioritize staff for a vaccine rollout while there is acute shortage of the vaccine. In spite of the availability of guidelines from state agencies, there is partial confusion about what an optimal rollout plan is. This...

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Autores principales: Bosbach, Wolfram A., Heinrich, Martin, Kolisch, Rainer, Heiss, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224649/
https://www.ncbi.nlm.nih.gov/pubmed/34067405
http://dx.doi.org/10.3390/vaccines9060546
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author Bosbach, Wolfram A.
Heinrich, Martin
Kolisch, Rainer
Heiss, Christian
author_facet Bosbach, Wolfram A.
Heinrich, Martin
Kolisch, Rainer
Heiss, Christian
author_sort Bosbach, Wolfram A.
collection PubMed
description Motive. The Covid-19 pandemic has led to the novel situation that hospitals must prioritize staff for a vaccine rollout while there is acute shortage of the vaccine. In spite of the availability of guidelines from state agencies, there is partial confusion about what an optimal rollout plan is. This study investigates effects in a hospital model under different rollout schemes. Methods. A simulation model is implemented in VBA, and is studied for parameter variation in a predefined hospital setting. The implemented code is available as open access supplement. Main results. A rollout scheme assigning vaccine doses to staff primarily by staff’s pathogen exposure maximizes the predicted open hospital capacity when compared to a rollout based on a purely hierarchical prioritization. The effect increases under resource scarcity and greater disease activity. Nursing staff benefits most from an exposure focused rollout. Conclusions. The model employs SARS-CoV-2 parameters; nonetheless, effects observable in the model are transferable to other infectious diseases. Necessary future prioritization plans need to consider pathogen characteristics and social factors.
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spelling pubmed-82246492021-06-25 Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool Bosbach, Wolfram A. Heinrich, Martin Kolisch, Rainer Heiss, Christian Vaccines (Basel) Article Motive. The Covid-19 pandemic has led to the novel situation that hospitals must prioritize staff for a vaccine rollout while there is acute shortage of the vaccine. In spite of the availability of guidelines from state agencies, there is partial confusion about what an optimal rollout plan is. This study investigates effects in a hospital model under different rollout schemes. Methods. A simulation model is implemented in VBA, and is studied for parameter variation in a predefined hospital setting. The implemented code is available as open access supplement. Main results. A rollout scheme assigning vaccine doses to staff primarily by staff’s pathogen exposure maximizes the predicted open hospital capacity when compared to a rollout based on a purely hierarchical prioritization. The effect increases under resource scarcity and greater disease activity. Nursing staff benefits most from an exposure focused rollout. Conclusions. The model employs SARS-CoV-2 parameters; nonetheless, effects observable in the model are transferable to other infectious diseases. Necessary future prioritization plans need to consider pathogen characteristics and social factors. MDPI 2021-05-22 /pmc/articles/PMC8224649/ /pubmed/34067405 http://dx.doi.org/10.3390/vaccines9060546 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bosbach, Wolfram A.
Heinrich, Martin
Kolisch, Rainer
Heiss, Christian
Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool
title Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool
title_full Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool
title_fullStr Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool
title_full_unstemmed Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool
title_short Maximization of Open Hospital Capacity under Shortage of SARS-CoV-2 Vaccines—An Open Access, Stochastic Simulation Tool
title_sort maximization of open hospital capacity under shortage of sars-cov-2 vaccines—an open access, stochastic simulation tool
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224649/
https://www.ncbi.nlm.nih.gov/pubmed/34067405
http://dx.doi.org/10.3390/vaccines9060546
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