Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health

The gut microbiota has been increasingly linked to metabolic health and disease over the last few decades. Several factors have been suggested to be involved in lipid metabolism and metabolic responses. One mediator that has gained great interest as a clinically important enzyme is bile salt hydrola...

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Autores principales: Bourgin, Mélanie, Kriaa, Aicha, Mkaouar, Héla, Mariaule, Vincent, Jablaoui, Amin, Maguin, Emmanuelle, Rhimi, Moez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224655/
https://www.ncbi.nlm.nih.gov/pubmed/34067328
http://dx.doi.org/10.3390/microorganisms9061122
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author Bourgin, Mélanie
Kriaa, Aicha
Mkaouar, Héla
Mariaule, Vincent
Jablaoui, Amin
Maguin, Emmanuelle
Rhimi, Moez
author_facet Bourgin, Mélanie
Kriaa, Aicha
Mkaouar, Héla
Mariaule, Vincent
Jablaoui, Amin
Maguin, Emmanuelle
Rhimi, Moez
author_sort Bourgin, Mélanie
collection PubMed
description The gut microbiota has been increasingly linked to metabolic health and disease over the last few decades. Several factors have been suggested to be involved in lipid metabolism and metabolic responses. One mediator that has gained great interest as a clinically important enzyme is bile salt hydrolase (BSH). BSH enzymes are widely distributed in human gastrointestinal microbial communities and are believed to play key roles in both microbial and host physiology. In this review, we discuss the current evidence related to the role of BSHs in health and provide useful insights that may pave the way for new therapeutic targets in human diseases.
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spelling pubmed-82246552021-06-25 Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health Bourgin, Mélanie Kriaa, Aicha Mkaouar, Héla Mariaule, Vincent Jablaoui, Amin Maguin, Emmanuelle Rhimi, Moez Microorganisms Review The gut microbiota has been increasingly linked to metabolic health and disease over the last few decades. Several factors have been suggested to be involved in lipid metabolism and metabolic responses. One mediator that has gained great interest as a clinically important enzyme is bile salt hydrolase (BSH). BSH enzymes are widely distributed in human gastrointestinal microbial communities and are believed to play key roles in both microbial and host physiology. In this review, we discuss the current evidence related to the role of BSHs in health and provide useful insights that may pave the way for new therapeutic targets in human diseases. MDPI 2021-05-22 /pmc/articles/PMC8224655/ /pubmed/34067328 http://dx.doi.org/10.3390/microorganisms9061122 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bourgin, Mélanie
Kriaa, Aicha
Mkaouar, Héla
Mariaule, Vincent
Jablaoui, Amin
Maguin, Emmanuelle
Rhimi, Moez
Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
title Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
title_full Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
title_fullStr Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
title_full_unstemmed Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
title_short Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
title_sort bile salt hydrolases: at the crossroads of microbiota and human health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224655/
https://www.ncbi.nlm.nih.gov/pubmed/34067328
http://dx.doi.org/10.3390/microorganisms9061122
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