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Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment...

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Autores principales: Pourafshar, Shirin, Nicchitta, Mira, Tyson, Crystal C., Svetkey, Laura P., Corcoran, David L., Bain, James R., Muehlbauer, Michael J., Ilkayeva, Olga, O’Connell, Thomas M., Lin, Pao-Hwa, Scialla, Julia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224662/
https://www.ncbi.nlm.nih.gov/pubmed/34067295
http://dx.doi.org/10.3390/nu13061768
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author Pourafshar, Shirin
Nicchitta, Mira
Tyson, Crystal C.
Svetkey, Laura P.
Corcoran, David L.
Bain, James R.
Muehlbauer, Michael J.
Ilkayeva, Olga
O’Connell, Thomas M.
Lin, Pao-Hwa
Scialla, Julia J.
author_facet Pourafshar, Shirin
Nicchitta, Mira
Tyson, Crystal C.
Svetkey, Laura P.
Corcoran, David L.
Bain, James R.
Muehlbauer, Michael J.
Ilkayeva, Olga
O’Connell, Thomas M.
Lin, Pao-Hwa
Scialla, Julia J.
author_sort Pourafshar, Shirin
collection PubMed
description We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet.
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spelling pubmed-82246622021-06-25 Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study Pourafshar, Shirin Nicchitta, Mira Tyson, Crystal C. Svetkey, Laura P. Corcoran, David L. Bain, James R. Muehlbauer, Michael J. Ilkayeva, Olga O’Connell, Thomas M. Lin, Pao-Hwa Scialla, Julia J. Nutrients Communication We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet. MDPI 2021-05-22 /pmc/articles/PMC8224662/ /pubmed/34067295 http://dx.doi.org/10.3390/nu13061768 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Pourafshar, Shirin
Nicchitta, Mira
Tyson, Crystal C.
Svetkey, Laura P.
Corcoran, David L.
Bain, James R.
Muehlbauer, Michael J.
Ilkayeva, Olga
O’Connell, Thomas M.
Lin, Pao-Hwa
Scialla, Julia J.
Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study
title Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study
title_full Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study
title_fullStr Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study
title_full_unstemmed Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study
title_short Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study
title_sort urine and plasma metabolome of healthy adults consuming the dash (dietary approaches to stop hypertension) diet: a randomized pilot feeding study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224662/
https://www.ncbi.nlm.nih.gov/pubmed/34067295
http://dx.doi.org/10.3390/nu13061768
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