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Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study
We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224662/ https://www.ncbi.nlm.nih.gov/pubmed/34067295 http://dx.doi.org/10.3390/nu13061768 |
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author | Pourafshar, Shirin Nicchitta, Mira Tyson, Crystal C. Svetkey, Laura P. Corcoran, David L. Bain, James R. Muehlbauer, Michael J. Ilkayeva, Olga O’Connell, Thomas M. Lin, Pao-Hwa Scialla, Julia J. |
author_facet | Pourafshar, Shirin Nicchitta, Mira Tyson, Crystal C. Svetkey, Laura P. Corcoran, David L. Bain, James R. Muehlbauer, Michael J. Ilkayeva, Olga O’Connell, Thomas M. Lin, Pao-Hwa Scialla, Julia J. |
author_sort | Pourafshar, Shirin |
collection | PubMed |
description | We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet. |
format | Online Article Text |
id | pubmed-8224662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82246622021-06-25 Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study Pourafshar, Shirin Nicchitta, Mira Tyson, Crystal C. Svetkey, Laura P. Corcoran, David L. Bain, James R. Muehlbauer, Michael J. Ilkayeva, Olga O’Connell, Thomas M. Lin, Pao-Hwa Scialla, Julia J. Nutrients Communication We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet. MDPI 2021-05-22 /pmc/articles/PMC8224662/ /pubmed/34067295 http://dx.doi.org/10.3390/nu13061768 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Pourafshar, Shirin Nicchitta, Mira Tyson, Crystal C. Svetkey, Laura P. Corcoran, David L. Bain, James R. Muehlbauer, Michael J. Ilkayeva, Olga O’Connell, Thomas M. Lin, Pao-Hwa Scialla, Julia J. Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study |
title | Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study |
title_full | Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study |
title_fullStr | Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study |
title_full_unstemmed | Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study |
title_short | Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study |
title_sort | urine and plasma metabolome of healthy adults consuming the dash (dietary approaches to stop hypertension) diet: a randomized pilot feeding study |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224662/ https://www.ncbi.nlm.nih.gov/pubmed/34067295 http://dx.doi.org/10.3390/nu13061768 |
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