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Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature
Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We r...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224668/ https://www.ncbi.nlm.nih.gov/pubmed/34071040 http://dx.doi.org/10.3390/medicina57060524 |
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author | Trabucco, Senia Maria Rosaria Brascia, Debora Cazzato, Gerardo De Iaco, Giulia Colagrande, Anna Signore, Francesca Ingravallo, Giuseppe Resta, Leonardo Marulli, Giuseppe |
author_facet | Trabucco, Senia Maria Rosaria Brascia, Debora Cazzato, Gerardo De Iaco, Giulia Colagrande, Anna Signore, Francesca Ingravallo, Giuseppe Resta, Leonardo Marulli, Giuseppe |
author_sort | Trabucco, Senia Maria Rosaria |
collection | PubMed |
description | Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We report our experience of two cases of sclerosing pneumocytoma, as well as a review of the literature. Immunohistochemical findings showed intense staining of the cuboidal epithelial cells for cytokeratin-pool and TTF-1, with focal positivity for progesterone receptors. Round and spindle cells expressed positivity for vimentin, TTF-1 and focally for the progesterone receptor. Cytologic diagnosis of pulmonary pneumocytoma requires the identification of its dual cell population, made up of abundant stromal cells and fewer surface cells. Since the pre- and intraoperative diagnosis should guide surgical decision making, obtaining a sufficient specimen size to find representative material in the cell block is of paramount importance. |
format | Online Article Text |
id | pubmed-8224668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82246682021-06-25 Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature Trabucco, Senia Maria Rosaria Brascia, Debora Cazzato, Gerardo De Iaco, Giulia Colagrande, Anna Signore, Francesca Ingravallo, Giuseppe Resta, Leonardo Marulli, Giuseppe Medicina (Kaunas) Review Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We report our experience of two cases of sclerosing pneumocytoma, as well as a review of the literature. Immunohistochemical findings showed intense staining of the cuboidal epithelial cells for cytokeratin-pool and TTF-1, with focal positivity for progesterone receptors. Round and spindle cells expressed positivity for vimentin, TTF-1 and focally for the progesterone receptor. Cytologic diagnosis of pulmonary pneumocytoma requires the identification of its dual cell population, made up of abundant stromal cells and fewer surface cells. Since the pre- and intraoperative diagnosis should guide surgical decision making, obtaining a sufficient specimen size to find representative material in the cell block is of paramount importance. MDPI 2021-05-23 /pmc/articles/PMC8224668/ /pubmed/34071040 http://dx.doi.org/10.3390/medicina57060524 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Trabucco, Senia Maria Rosaria Brascia, Debora Cazzato, Gerardo De Iaco, Giulia Colagrande, Anna Signore, Francesca Ingravallo, Giuseppe Resta, Leonardo Marulli, Giuseppe Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature |
title | Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature |
title_full | Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature |
title_fullStr | Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature |
title_full_unstemmed | Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature |
title_short | Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature |
title_sort | pulmonary sclerosing pneumocytoma: a pre and intraoperative diagnostic challenge. report of two cases and review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224668/ https://www.ncbi.nlm.nih.gov/pubmed/34071040 http://dx.doi.org/10.3390/medicina57060524 |
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