Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers

Epithelial to mesenchymal transition (EMT) is a process that allows epithelial cells to progressively acquire a reversible mesenchymal phenotype. Here, we recount the main events in the history of EMT. EMT was first studied during embryonic development. Nowadays, it is an important field in cancer r...

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Detalles Bibliográficos
Autores principales: Lachat, Camille, Peixoto, Paul, Hervouet, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224685/
https://www.ncbi.nlm.nih.gov/pubmed/34067395
http://dx.doi.org/10.3390/biom11060782
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author Lachat, Camille
Peixoto, Paul
Hervouet, Eric
author_facet Lachat, Camille
Peixoto, Paul
Hervouet, Eric
author_sort Lachat, Camille
collection PubMed
description Epithelial to mesenchymal transition (EMT) is a process that allows epithelial cells to progressively acquire a reversible mesenchymal phenotype. Here, we recount the main events in the history of EMT. EMT was first studied during embryonic development. Nowadays, it is an important field in cancer research, studied all around the world by more and more scientists, because it was shown that EMT is involved in cancer aggressiveness in many different ways. The main features of EMT’s involvement in embryonic development, fibrosis and cancers are briefly reviewed here.
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spelling pubmed-82246852021-06-25 Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers Lachat, Camille Peixoto, Paul Hervouet, Eric Biomolecules Review Epithelial to mesenchymal transition (EMT) is a process that allows epithelial cells to progressively acquire a reversible mesenchymal phenotype. Here, we recount the main events in the history of EMT. EMT was first studied during embryonic development. Nowadays, it is an important field in cancer research, studied all around the world by more and more scientists, because it was shown that EMT is involved in cancer aggressiveness in many different ways. The main features of EMT’s involvement in embryonic development, fibrosis and cancers are briefly reviewed here. MDPI 2021-05-22 /pmc/articles/PMC8224685/ /pubmed/34067395 http://dx.doi.org/10.3390/biom11060782 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lachat, Camille
Peixoto, Paul
Hervouet, Eric
Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers
title Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers
title_full Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers
title_fullStr Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers
title_full_unstemmed Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers
title_short Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers
title_sort epithelial to mesenchymal transition history: from embryonic development to cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224685/
https://www.ncbi.nlm.nih.gov/pubmed/34067395
http://dx.doi.org/10.3390/biom11060782
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