Cargando…

Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk

Q fever is a zoonotic disease that is caused by Coxiella burnetii and leads to abortion and infertility in ruminants and debilitating disease in humans. Jimma zone, including Jimma town, located in the Oromia region of Ethiopia, was affected by an outbreak of abortions in ruminants related to Q feve...

Descripción completa

Detalles Bibliográficos
Autores principales: Proboste, Tatiana, Deressa, Feyissa Begna, Li, Yanjin, Kal, David Onafruo, Gelalcha, Benti Deressa, Soares Magalhães, Ricardo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224686/
https://www.ncbi.nlm.nih.gov/pubmed/34071090
http://dx.doi.org/10.3390/pathogens10060646
_version_ 1783711940982341632
author Proboste, Tatiana
Deressa, Feyissa Begna
Li, Yanjin
Kal, David Onafruo
Gelalcha, Benti Deressa
Soares Magalhães, Ricardo J.
author_facet Proboste, Tatiana
Deressa, Feyissa Begna
Li, Yanjin
Kal, David Onafruo
Gelalcha, Benti Deressa
Soares Magalhães, Ricardo J.
author_sort Proboste, Tatiana
collection PubMed
description Q fever is a zoonotic disease that is caused by Coxiella burnetii and leads to abortion and infertility in ruminants and debilitating disease in humans. Jimma zone, including Jimma town, located in the Oromia region of Ethiopia, was affected by an outbreak of abortions in ruminants related to Q fever infection between 2013 and 2015. This study aimed to investigate the geo-clustering of C. burnetii seroprevalence in dairy farms of Jimma town and identify the environmental risk factors associated with seroprevalence distribution. A total of 227 cattle were tested for antibodies against C. burnetii in 25 farms. We explored the clustering of C. burnetii seroprevalence using semivariograms. A geostatistical regression-based model was implemented to quantify the risk factors and to predict the geographical variation in C. burnetii seroprevalence at unsampled locations in Jimma town using OpenBugs. Our results demonstrated that the risk of exposure in dairy cattle varied across the landscape of Jimma town and was associated with environmental risk factors. The predictive map of C. burnetii seroprevalence showed that communities in the eastern part of Jimma town had the highest risk of exposure. Our results can inform community-level investigations of human seroprevalence in the high-risk areas to the east of Jimma.
format Online
Article
Text
id pubmed-8224686
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82246862021-06-25 Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk Proboste, Tatiana Deressa, Feyissa Begna Li, Yanjin Kal, David Onafruo Gelalcha, Benti Deressa Soares Magalhães, Ricardo J. Pathogens Article Q fever is a zoonotic disease that is caused by Coxiella burnetii and leads to abortion and infertility in ruminants and debilitating disease in humans. Jimma zone, including Jimma town, located in the Oromia region of Ethiopia, was affected by an outbreak of abortions in ruminants related to Q fever infection between 2013 and 2015. This study aimed to investigate the geo-clustering of C. burnetii seroprevalence in dairy farms of Jimma town and identify the environmental risk factors associated with seroprevalence distribution. A total of 227 cattle were tested for antibodies against C. burnetii in 25 farms. We explored the clustering of C. burnetii seroprevalence using semivariograms. A geostatistical regression-based model was implemented to quantify the risk factors and to predict the geographical variation in C. burnetii seroprevalence at unsampled locations in Jimma town using OpenBugs. Our results demonstrated that the risk of exposure in dairy cattle varied across the landscape of Jimma town and was associated with environmental risk factors. The predictive map of C. burnetii seroprevalence showed that communities in the eastern part of Jimma town had the highest risk of exposure. Our results can inform community-level investigations of human seroprevalence in the high-risk areas to the east of Jimma. MDPI 2021-05-23 /pmc/articles/PMC8224686/ /pubmed/34071090 http://dx.doi.org/10.3390/pathogens10060646 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Proboste, Tatiana
Deressa, Feyissa Begna
Li, Yanjin
Kal, David Onafruo
Gelalcha, Benti Deressa
Soares Magalhães, Ricardo J.
Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk
title Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk
title_full Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk
title_fullStr Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk
title_full_unstemmed Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk
title_short Geographical Variation in Coxiella burnetii Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk
title_sort geographical variation in coxiella burnetii seroprevalence in dairy farms located in south-western ethiopia: understanding the broader community risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224686/
https://www.ncbi.nlm.nih.gov/pubmed/34071090
http://dx.doi.org/10.3390/pathogens10060646
work_keys_str_mv AT probostetatiana geographicalvariationincoxiellaburnetiiseroprevalenceindairyfarmslocatedinsouthwesternethiopiaunderstandingthebroadercommunityrisk
AT deressafeyissabegna geographicalvariationincoxiellaburnetiiseroprevalenceindairyfarmslocatedinsouthwesternethiopiaunderstandingthebroadercommunityrisk
AT liyanjin geographicalvariationincoxiellaburnetiiseroprevalenceindairyfarmslocatedinsouthwesternethiopiaunderstandingthebroadercommunityrisk
AT kaldavidonafruo geographicalvariationincoxiellaburnetiiseroprevalenceindairyfarmslocatedinsouthwesternethiopiaunderstandingthebroadercommunityrisk
AT gelalchabentideressa geographicalvariationincoxiellaburnetiiseroprevalenceindairyfarmslocatedinsouthwesternethiopiaunderstandingthebroadercommunityrisk
AT soaresmagalhaesricardoj geographicalvariationincoxiellaburnetiiseroprevalenceindairyfarmslocatedinsouthwesternethiopiaunderstandingthebroadercommunityrisk