Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug–Drug Interaction in Healthy Volunteers

In this study, we aimed to evaluate the utility of endogenous 1β-hydroxy-deoxycholic acid/total deoxycholic acid ratio (1β-OH-DCA/ToDCA) in spot urine as a surrogate marker of cytochrome P450 3A (CYP3A) activity in the assessment inhibition-based drug–drug interactions in healthy volunteers. This wa...

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Detalles Bibliográficos
Autores principales: Li, Xue-Qing, Thelingwani, Roslyn Stella, Bertilsson, Leif, Diczfalusy, Ulf, Andersson, Tommy B., Masimirembwa, Collen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224742/
https://www.ncbi.nlm.nih.gov/pubmed/34073662
http://dx.doi.org/10.3390/jpm11060457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224742/
https://www.ncbi.nlm.nih.gov/pubmed/34073662
http://dx.doi.org/10.3390/jpm11060457

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