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Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis
Maintaining cholesterol homeostasis is essential for normal cellular and systemic functions. Long non-coding RNAs (lncRNAs) represent a mechanism to fine-tune numerous biological processes by controlling gene expression. LncRNAs have emerged as important regulators in cholesterol homeostasis. Dysreg...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224755/ https://www.ncbi.nlm.nih.gov/pubmed/34179148 http://dx.doi.org/10.3389/fcvm.2021.688546 |
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author | Ye, Wen-Chu Huang, Shi-Feng Hou, Lian-Jie Long, Hai-Jiao Yin, Kai Hu, Ching Yuan Zhao, Guo-Jun |
author_facet | Ye, Wen-Chu Huang, Shi-Feng Hou, Lian-Jie Long, Hai-Jiao Yin, Kai Hu, Ching Yuan Zhao, Guo-Jun |
author_sort | Ye, Wen-Chu |
collection | PubMed |
description | Maintaining cholesterol homeostasis is essential for normal cellular and systemic functions. Long non-coding RNAs (lncRNAs) represent a mechanism to fine-tune numerous biological processes by controlling gene expression. LncRNAs have emerged as important regulators in cholesterol homeostasis. Dysregulation of lncRNAs expression is associated with lipid-related diseases, suggesting that manipulating the lncRNAs expression could be a promising therapeutic approach to ameliorate liver disease progression and cardiovascular disease (CVD). However, given the high-abundant lncRNAs and the poor genetic conservation between species, much work is required to elucidate the specific role of lncRNAs in regulating cholesterol homeostasis. In this review, we highlighted the latest advances in the pivotal role and mechanism of lncRNAs in regulating cholesterol homeostasis. These findings provide novel insights into the underlying mechanisms of lncRNAs in lipid-related diseases and may offer potential therapeutic targets for treating lipid-related diseases. |
format | Online Article Text |
id | pubmed-8224755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82247552021-06-25 Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis Ye, Wen-Chu Huang, Shi-Feng Hou, Lian-Jie Long, Hai-Jiao Yin, Kai Hu, Ching Yuan Zhao, Guo-Jun Front Cardiovasc Med Cardiovascular Medicine Maintaining cholesterol homeostasis is essential for normal cellular and systemic functions. Long non-coding RNAs (lncRNAs) represent a mechanism to fine-tune numerous biological processes by controlling gene expression. LncRNAs have emerged as important regulators in cholesterol homeostasis. Dysregulation of lncRNAs expression is associated with lipid-related diseases, suggesting that manipulating the lncRNAs expression could be a promising therapeutic approach to ameliorate liver disease progression and cardiovascular disease (CVD). However, given the high-abundant lncRNAs and the poor genetic conservation between species, much work is required to elucidate the specific role of lncRNAs in regulating cholesterol homeostasis. In this review, we highlighted the latest advances in the pivotal role and mechanism of lncRNAs in regulating cholesterol homeostasis. These findings provide novel insights into the underlying mechanisms of lncRNAs in lipid-related diseases and may offer potential therapeutic targets for treating lipid-related diseases. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8224755/ /pubmed/34179148 http://dx.doi.org/10.3389/fcvm.2021.688546 Text en Copyright © 2021 Ye, Huang, Hou, Long, Yin, Hu and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Ye, Wen-Chu Huang, Shi-Feng Hou, Lian-Jie Long, Hai-Jiao Yin, Kai Hu, Ching Yuan Zhao, Guo-Jun Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis |
title | Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis |
title_full | Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis |
title_fullStr | Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis |
title_full_unstemmed | Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis |
title_short | Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis |
title_sort | potential therapeutic targeting of lncrnas in cholesterol homeostasis |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224755/ https://www.ncbi.nlm.nih.gov/pubmed/34179148 http://dx.doi.org/10.3389/fcvm.2021.688546 |
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