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Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature
Total pancreatectomy (TP) is a highly invasive procedure often performed in patients affected by anorexia, malabsorption, cachexia, and malnutrition, which are risk factors for bad surgical outcome and even may cause enhanced toxicity to chemo-radiotherapy. The role of nutritional therapies and the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224756/ https://www.ncbi.nlm.nih.gov/pubmed/34067286 http://dx.doi.org/10.3390/nu13061765 |
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author | Furbetta, Niccolò Comandatore, Annalisa Gianardi, Desirée Palmeri, Matteo Di Franco, Gregorio Guadagni, Simone Caprili, Giovanni Bianchini, Matteo Fatucchi, Lorenzo Maria Picchi, Martina Bastiani, Luca Biancofiore, Giandomenico Di Candio, Giulio Morelli, Luca |
author_facet | Furbetta, Niccolò Comandatore, Annalisa Gianardi, Desirée Palmeri, Matteo Di Franco, Gregorio Guadagni, Simone Caprili, Giovanni Bianchini, Matteo Fatucchi, Lorenzo Maria Picchi, Martina Bastiani, Luca Biancofiore, Giandomenico Di Candio, Giulio Morelli, Luca |
author_sort | Furbetta, Niccolò |
collection | PubMed |
description | Total pancreatectomy (TP) is a highly invasive procedure often performed in patients affected by anorexia, malabsorption, cachexia, and malnutrition, which are risk factors for bad surgical outcome and even may cause enhanced toxicity to chemo-radiotherapy. The role of nutritional therapies and the association between nutritional aspects and the outcome of patients who have undergone TP is described in some studies. The aim of this comprehensive review is to summarize the available recent evidence about the influence of nutritional factors in TP. Preoperative nutritional and metabolic assessment, but also intra-operative and post-operative nutritional therapies and their consequences, are analyzed in order to identify the aspects that can influence the outcome of patients undergoing TP. The results of this review show that preoperative nutritional status, sarcopenia, BMI and serum albumin are prognostic factors both in TP for pancreatic cancer to support chemotherapy, prevent recurrence and prolong survival, and in TP with islet auto-transplantation for chronic pancreatitis to improve postoperative glycemic control and obtain better outcomes. When it is possible, enteral nutrition is always preferable to parenteral nutrition, with the aim to prevent or reduce cachexia. Nowadays, the nutritional consequences of TP, including diabetes control, are improved and become more manageable. |
format | Online Article Text |
id | pubmed-8224756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82247562021-06-25 Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature Furbetta, Niccolò Comandatore, Annalisa Gianardi, Desirée Palmeri, Matteo Di Franco, Gregorio Guadagni, Simone Caprili, Giovanni Bianchini, Matteo Fatucchi, Lorenzo Maria Picchi, Martina Bastiani, Luca Biancofiore, Giandomenico Di Candio, Giulio Morelli, Luca Nutrients Review Total pancreatectomy (TP) is a highly invasive procedure often performed in patients affected by anorexia, malabsorption, cachexia, and malnutrition, which are risk factors for bad surgical outcome and even may cause enhanced toxicity to chemo-radiotherapy. The role of nutritional therapies and the association between nutritional aspects and the outcome of patients who have undergone TP is described in some studies. The aim of this comprehensive review is to summarize the available recent evidence about the influence of nutritional factors in TP. Preoperative nutritional and metabolic assessment, but also intra-operative and post-operative nutritional therapies and their consequences, are analyzed in order to identify the aspects that can influence the outcome of patients undergoing TP. The results of this review show that preoperative nutritional status, sarcopenia, BMI and serum albumin are prognostic factors both in TP for pancreatic cancer to support chemotherapy, prevent recurrence and prolong survival, and in TP with islet auto-transplantation for chronic pancreatitis to improve postoperative glycemic control and obtain better outcomes. When it is possible, enteral nutrition is always preferable to parenteral nutrition, with the aim to prevent or reduce cachexia. Nowadays, the nutritional consequences of TP, including diabetes control, are improved and become more manageable. MDPI 2021-05-22 /pmc/articles/PMC8224756/ /pubmed/34067286 http://dx.doi.org/10.3390/nu13061765 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Furbetta, Niccolò Comandatore, Annalisa Gianardi, Desirée Palmeri, Matteo Di Franco, Gregorio Guadagni, Simone Caprili, Giovanni Bianchini, Matteo Fatucchi, Lorenzo Maria Picchi, Martina Bastiani, Luca Biancofiore, Giandomenico Di Candio, Giulio Morelli, Luca Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature |
title | Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature |
title_full | Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature |
title_fullStr | Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature |
title_full_unstemmed | Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature |
title_short | Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature |
title_sort | perioperative nutritional aspects in total pancreatectomy: a comprehensive review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224756/ https://www.ncbi.nlm.nih.gov/pubmed/34067286 http://dx.doi.org/10.3390/nu13061765 |
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